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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Jaebum Park McShane, M. |
| Copyright Year | 2009 |
| Description | Author affiliation: Materials Science and Engineering, Texas A&M University, College Station, 77843 USA (Jaebum Park) || Department of Biomedical Engineering, Materials Science and Engineering, Texas A&M University, College Station, 77843 USA (McShane, M.) |
| Abstract | Ultrathin nanofilm coatings can play a key role for micro/nanoscale biosensor applications. Most flux-based enzymatic biosensors require incorporation of a diffusion-limiting coating to balance the flux of incoming substrates with reaction kinetics to obtain a measurable signal. Furthermore, the outer surface requires resistance to nonspecific adsorption of protein to prevent cell adhesion and host response initiation when deployed in vivo. However, materials suited for application to micro/nanoscale sensors are difficult to find. Polyelectrolyte mutilayers (PEMs) deposited via layer-by-layer (LbL) self-assembly are attractive solutions, as they offer nanocomposite films with tunable properties such as permeability and biocompatibility. In this paper, we explored the diffusion characteristics of nanofilms with different compositions including biocompatible surfaces, and investigated multiple analytes such as glucose, urea, and L-lactate to assess universal applications of these nanofilms as biosensor coatings. |
| Starting Page | 1208 |
| Ending Page | 1211 |
| File Size | 705876 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424445486 |
| ISSN | 19300395 |
| DOI | 10.1109/ICSENS.2009.5398364 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-10-25 |
| Publisher Place | New Zealand |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Coatings Biosensors Surface resistance Kinetic theory Electrical resistance measurement Immune system Proteins Adhesives In vivo Biological materials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Electrical and Electronic Engineering |
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