NDLI: The reduced ph method with indirect plasma for safe and effective disinfection in dentistry and surgery

Content Provider	IEEE Xplore Digital Library
Author	Kitano, K. Ikawa, S. Tani, A. Yamazaki, H. Ohshima, T. Kaneko, K. Ito, M. Kuwata, T. Yagishita, A.
Copyright Year	2012
Description	Author affiliation: Graduate School of Science, Osaka University, Japan (Tani, A.) \|\| Graduate School of Dental Medicine, Tsurumi Univ., Japan (Yamazaki, H.; Ohshima, T.) \|\| National Cancer Center Hospital East, Japan (Kaneko, K.; Ito, M.; Kuwata, T.; Yagishita, A.) \|\| Graduate School of Engineering, Osaka University, Japan (Kitano, K.) \|\| Technology Research Institute of Osaka Prefecture, Japan (Ikawa, S.)
Abstract	For the purpose of disinfecting human bodies in dental and surgical therapies, sterilization experiments in solution have been conducted with low-temperature atmospheric-pressure plasmas. For the plasma disinfection in the body fluid, we have successfully developed the reduced pH method that strong bactericidal activity can be achieved when the solution is sufficiently acidic [1]. It is interesting that a critical pH value of about 4.7 exists for the bactericidal activity. This critical value may be associated with pKa of the dissociation equilibrium between superoxide anion radicals $(O^{−}•)$ and hydroperoxy radicals (HOO•), which is known to be approximately 4.8. As the nature without electric charge, HOO• can diffuse into bacterial cytosol via hydrophobic cell membrane, therefore HOO• shows extremely stronger bactericidal activity than negative charged $O^{−}•.$ $O^{−}•$ generated in gas penetrate into liquid via plasma-air-liquid interactions [2, 3]. For the enough long lifetime of $O^{−}•$ in gas as air ion, $O^{−}•$ can be supplied into liquid by non-contact plasma. The non-contact plasma with 400 cm extra tube has e quivalent strong bactericidal activity only with the reduced pH method. In addition, we found that the plasma treated water has strong bactericidal activity for a few minutes with the reduced pH method. This suggests that the disinfection can be done by the plasma treated water which contains short-lived active species (cannot supplied by chemical reagent) and it would bring safety plasma medicine considering usual contact or non-contact plasmas to human body. Currently, animal experiments for root canal therapy in dentistry [4] and surgical site infection prevention in surgery have been done with indirect plasma disinfection techniques of non-contact plasma and plasma treated water.
File Size	95073
File Format	PDF
ISBN	9781457721274
ISSN	07309244
e-ISBN	9781457721298
e-ISBN	9781457721281
DOI	10.1109/PLASMA.2012.6383780
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-07-08
Publisher Place	United Kingdom
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Plasmas Dentistry Educational institutions Surgery Liquids Indium tin oxide
Content Type	Text
Resource Type	Article
Subject	Atomic and Molecular Physics, and Optics Condensed Matter Physics Electrical and Electronic Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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