NDLI: The effect of non-rigid misregistration in sequential quantitative SPECT for targeted radionuclide therapy

Content Provider	IEEE Xplore Digital Library
Author	Mok, G.S.P. Ao, E.C.I. Na Song Frey, E.C.
Copyright Year	2012
Description	Author affiliation: Dept. of Radiol., Johns Hopkins Univ., Baltimore, MD, USA (Frey, E.C.) \|\| Dept. of Electr. & Comput. Eng., Univ. of Macau, Macau, China (Mok, G.S.P.; Ao, E.C.I.) \|\| Dept. of Nucl. Med., Yeshiva Univ., New York, NY, USA (Na Song)
Abstract	Non-rigid organ misregistration is an important problem for patients undergoing sequential quantitative SPECT for 3D dosimetry for targeted radionuclide therapy (TRT) treatment planning. This study aims to evaluate effects of these misregistrations on the accuracy of 3D dosimetry. We used 3 anatomical variations and 3 respective In-Ill Zevalin distributions of the digital 4D Extended Cardiac Torso (XCAT) phantom to model the deformation in different organs such as liver, kidneys, spleen and stomach. We simulated SPECT scans acquired at 5 time points, i.e., 1, 12, 24, 72 and 144 hrs postinjection of $^{111}In$ Zevalin. Organs with uniform activity concentrations were randomly translated and rotated within 5 pixels/degrees, while the change of the total volume of each organ was within 5% except for the stomach. The 24-hr scan served as a reference. An analytical projector modeling attenuation, scatter and the geometric collimator-detector-response of a medium energy collimator was used to generate noisy projections representing a realistic count level for 128 views over 360°. Reconstructed images were obtained using OS-EM with attenuation, scatter and geometric collimator-detector-response compensation. Voxel-by-voxel integration over different time points followed by convolution with a $^{90}Y$ dose kernel was used to generate 3D dose distribution images. For each phantom, we compared the organ dose and its dose volume histogram (DVH) for (i) no organ deformation and (ii) organs with deformation. The mean difference of organ doses between two sets of images were 3.88%, -6.73%, -7.32% and -14.42% for lung, liver, kidneys and spleen respectively. However, even for the organs with dose errors <;5%, the associated normalized absolute errors in DVH were >10%. We conclude that organ misregistration a
Sponsorship	IEEE Nucl. Plasma Sci. Soc
Starting Page	2938
Ending Page	2941
File Size	940322
Page Count	4
File Format	PDF
ISBN	9781467320283
ISSN	10823654
e-ISBN	9781467320306
DOI	10.1109/NSSMIC.2012.6551671
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-27
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Content Type	Text
Resource Type	Article

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