NDLI: A novel method for the estimation of infarct size in a reperfused rat model for pinhole SPECT

Content Provider	IEEE Xplore Digital Library
Author	Bal, H. Thomas, D. Zixiong Cao Ferrari, V. Horowitz, J. Acton, P.D.
Copyright Year	2005
Abstract	Cardiac SPECT imaging using pinhole collimators can be used to perform in-vivo rat studies in order to evaluate cardiovascular diseases. The estimation of infarct size in a rat model of coronary artery disease, with [/sup 99m/Tc]sestamibi, is typically done using a single threshold for all the studies. However, the presence of high statistical noise in the data can result in inaccuracies in the infarct size estimates. In this work, a novel method of obtaining infarct sizes using a variation-dependant threshold and spatial information is proposed. First, the mouse body (MOBY) phantom was used to simulate a wide range of infarct sizes for high and low count statistics. In addition, experimental studies consisting of five control and thirteen reperfused rat studies with [/sup 99m/Tc]sestamibi were performed, by scanning each rat for 1 hr on the pinhole SPECT system. The projection data were reconstructed with OS-EM with penetration compensation and reoriented into short-axis slices. Circumferential profiles were obtained for each study. A relationship was obtained between the threshold and the variation in circumferential profiles for all the control studies. Using this relationship, a threshold was computed for each reperfused study. Since the site of occlusion was known, a region growing technique along with the selected threshold were used to obtain an estimate of the infarct size. The infarct sizes obtained with the proposed method were closer to the corresponding true infarct sizes, in the case of simulated data and triphenyltetrazolium chloride (TTC) staining derived infarct sizes, in the case of experimental rat studies, than those with a constant threshold. The proposed method has the potential to provide accurate estimates of infarct sizes for in-vivo rat studies performed with pinhole SPECT.
Starting Page	4
Ending Page	1789
File Size	1164661
Page Count	1786
File Format	PDF
ISBN	0780392213
ISSN	10957863
DOI	10.1109/NSSMIC.2005.1596667
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-10-23
Publisher Place	Puerto Rico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Collimators Performance evaluation Cardiovascular diseases Coronary arteriosclerosis Mice Imaging phantoms Statistics Control systems Heart rate Image reconstruction
Content Type	Text
Resource Type	Article

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