NDLI: Quantification of myocardial blood flow with /sup 13/N-ammonia and /sup 82/Rb PET

Content Provider	IEEE Xplore Digital Library
Author	Davies, R.W. Renaud, J.M. Beanlands, R.S. deKemp, R.A.
Copyright Year	2005
Description	Author affiliation: Heart Inst., Ottawa Univ., Ont. (Davies, R.W.; Renaud, J.M.; Beanlands, R.S.; deKemp, R.A.)
Abstract	OSEM is a standard for image reconstruction in positron emission tomography (PET). However, OSEM has not been compared with filtered back projection (FBP) for the quantification of myocardial blood flow (MBF) with $^{13}N-ammonia$ (NH3) and $^{82}Rb$ PET. 12 subjects with <5% likelihood of CAD had rest and stress (dipyridamole) dynamic PET with NH3 and Rb. Arterial blood and myocardial polar-map time activity curves were generated automatically and used with tracer kinetic models for quantification of MBF. A 1-compartment model was used for Rb and a 2-compartment model for NH3 to estimate the regional uptake rate constant $K_{1}.$ Normal population databases were also created for NH3 and Rb using a net retention model. The databases comprised population mean and standard deviation (SD) polar-maps at rest, stress and stress/rest. There were no consistent differences between LV-median $K_{1}$ values generated with OSEM or FBP, although the rest NH3 $K_{1}$ value did decrease by 16% with OSEM (p=0.01). Peak blood values were consistently reduced by 5-10% with OSEM. At rest, the normal population database SD with OSEM was 10% higher for Rb (p=0.02) and 5% higher for NH3 (p=0.02). Conversely, the stress SD was decreased by 15% with OSEM for Rb (p<0.001) and 9% for NH3 (p<0.001). Stress/rest SD also decreased with OSEM by 15% for NH3 (p<0.001), and tended to decrease by 4% for Rb (p=0.12). The measured normal range (population SD) of stress flow and stress/rest reserve appears to be smaller with OSEM vs. FBP, which may be advantageous for the diagnosis of CAD with Rb and NH3 PET
Starting Page	2117
Ending Page	2119
File Size	214192
Page Count	3
File Format	PDF
ISBN	0780392213
ISSN	10957863
DOI	10.1109/NSSMIC.2005.1596752
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-10-23
Publisher Place	Puerto Rico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Myocardium Blood flow Positron emission tomography Stress Image reconstruction Coronary arteriosclerosis Databases Whole-body PET Fluid flow measurement Heart
Content Type	Text
Resource Type	Article

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