NDLI: Construction details of an autoradiographic-based rat brain phantom for emission tomography

Content Provider	IEEE Xplore Digital Library
Author	Dougherty, D.A. Nissanov, J. Gindi, G.R.
Copyright Year	1999
Description	Author affiliation: Dept. of Anatomy, State Univ. of New York, Stony Brook, NY, USA (Dougherty, D.A.)
Abstract	A digital brain phantom was created from rat brain autoradiographic (AR) data for use in emission computed tomography studies. The animal tissue was radio-labeled with [/sup 14/C]-2-deoxyglucose, a functional analog of the PET agent [/sup 18/F]-fluro-deoxyglucose. Following sacrifice of the animal, serial tissue sections were cut at 20 /spl mu/m thickness, digitized, and calibrated to represent the ground truth 2D relative spatial distribution of radionuclide within the tissue. A 3D representation was achieved by digital alignment of the serial AR images to corresponding video blockface images acquired at the time of cutting. In addition, a magnetic resonance data set was co-registered to the AR and blockface data using the AIR algorithm. This paper is concerned with outlining the details of construction for this phantom.
Starting Page	1250
Ending Page	1254
File Size	605070
Page Count	5
File Format	PDF
ISBN	0780350219
ISSN	10823654
DOI	10.1109/NSSMIC.1998.774384
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1998-11-08
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Imaging phantoms Animals Image reconstruction Image segmentation Skull Positron emission tomography Medical tests Nuclear medicine Image quality Testing
Content Type	Text
Resource Type	Article

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