NDLI: Implementation of a combined X-ray CT-scintillation camera imaging system for localizing and measuring radionuclide uptake: experiments in phantoms and patients

Content Provider	IEEE Xplore Digital Library
Author	Tang, H.R. Brown, J.K. Da Silva, A.J. Matthay, K.K. Price, D.C. Hawkins, R.A. Hasegawa, B.H. Matthay, K.K.
Copyright Year	1999
Description	Author affiliation: Dept. of Radiol., California Univ., San Francisco, CA, USA (Tang, H.R.)
Abstract	We have developed and demonstrated an imaging system that couples an X-ray CT scanner to a scintillation camera for the localization and absolute measurement of radionuclide uptake. We use the registered CT images to provide physical information to overcome the quantitative errors in nuclear imaging due to attenuation, scatter, and limited spatial resolution. The registration accuracy and precision in phantom experiments was 0.0/spl plusmn/0.4 mm. Preliminary patient scans suggest that the registration techniques developed for phantom studies can be used. Conversion of X-ray CT image data to attenuation maps was accomplished by the scaling of calibration data and includes extensions to account for the presence of iodinated contrast agents. Experimental phantom studies show absolute quantitation with less than 10% error for up to 2:1 target:background activity concentration for objects as small as 2.7 ml. We are evaluating the localization and absolute quantitation of /sup 131/I-MIBG in neuroblastoma patients to determine if the techniques improve correlation between tumor dose and response.
Starting Page	1243
Ending Page	1249
File Size	787648
Page Count	7
File Format	PDF
ISBN	0780350219
ISSN	10823654
DOI	10.1109/NSSMIC.1998.774383
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1998-11-08
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	X-ray imaging Cameras Optical imaging Computed tomography Imaging phantoms Attenuation Nuclear imaging X-ray scattering Spatial resolution Image converters
Content Type	Text
Resource Type	Article

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