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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Takamatsu, R. Oura, H. Uchida, T. Ikeda, S. Arai, F. Negoro, M. Hayakawa, M. Takahashi, I. Fukuda, T. |
| Copyright Year | 2009 |
| Description | Author affiliation: Department of Bioengineering and Robotics, Tohoku University, Sendai, 980-8579, Japan (Arai, F.) || Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya 464-8603, Japan (Takamatsu, R.; Oura, H.; Uchida, T.; Ikeda, S.; Fukuda, T.) || Department of Neurological Surgery, Anjo Kosei Hospital, Anjo, Aichi, 446-8602, Japan (Takahashi, I.) || Department of Neurological Surgery, Fujita Health University, Toyoake, Aichi, 470-1192, Japan (Negoro, M.; Hayakawa, M.) |
| Abstract | Technologies to develop scaffolds with controlled diameter and high porosity have great significance in tissue engineering. We have fabricated biodegradable 2D and 3D scaffolds with ordered array of pores by casting polymer on self-assembled d-fructose (sugar) microspheres. First, ferrite mi croparticles were encapsulated in sugar spheres to make th em become magnetized. After sieving magnetic sugar particles, those diameter-controlled particles were attracted by a magnet to form a self-assembled template for polymer casting. After removal of sugar particles, ordered array of po res were generated on the surface of sheet-like scaffolds. Ordered pores are also generated in 3D tubular scaffolds by using magnetic force and viscoelasticity of PVA solution. It was confirmed that MSPs leaching method makes it possible to make high porous scaffolds in spite of the thickness of scaffold and the porosity is homogeneous. Finally, the biocompatibility of the developed scaffold was confirmed by the viability of human umbilical vein endothelial cells. |
| Starting Page | 356 |
| Ending Page | 361 |
| File Size | 853843 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781424450947 |
| DOI | 10.1109/MHS.2009.5351884 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-11-09 |
| Publisher Place | Japan |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Biodegradable materials Leaching Casting Polymers Tissue engineering Ferrites Magnetic forces Viscosity Elasticity Humans |
| Content Type | Text |
| Resource Type | Article |
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