NDLI: Fabrication of Cell-Adhesion Surface and Capillary Vessel Model by Photolithography

Content Provider	IEEE Xplore Digital Library
Author	Nakano, T. Tada, M. Yu-Ching Lin Ikeda, S. Uchida, T. Oura, H. Fukuda, T. Matsuda, T. Negoro, M. Arai, F.
Copyright Year	2007
Description	Author affiliation: Tohoku Univ., Sendai (Nakano, T.; Tada, M.; Yu-Ching Lin)
Abstract	We have been developing scaffolds of three-dimensional (3D) synthetic vascular prosthesis in tailor-made. Human umbilical vein endothelial cells (HUVECs) attached on the inner surface of the scaffold have anticoagulant effects. Asperity structures of the inner surface are important to cell adhesion. It is important to quantify the inner surface asperity condition of the scaffold by observing HUVECs behavior and morphology. For this purpose, we recreated the inner surface profile of the scaffold on a poly(dimethilsiloxane) (PDMS) substrate by microfabrication. We made semiround convex patterns of resist that had 8 mum in diameter and 5 mum high using photolithography, and the concave pattern on the PDMS substrate by printing. We observed HUVECs adhering to the PDMS substrate having concave pattern on it surface. The distribution density of the concaves of the tested pattern is 1600 $/mm^{2}$ or 40,000 in a 25 $mm^{2}$ area. In addition, we fabricated a capillary vessel model by photolithography, creating a branched capillary tube model that had 13 mum in diameter. We confirmed that the capillary vessel model had no leakage using a methylene blue solution flow in the channel.
Starting Page	350
Ending Page	355
File Size	5195806
Page Count	6
File Format	PDF
ISBN	9781424418572
DOI	10.1109/MHS.2007.4420879
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-11-11
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Fabrication Lithography Surface morphology Prosthetics Humans Veins Adhesives Resists Printing Testing regenerative medicine endothelial cell photolithography biology blood vessel
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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