NDLI: Mechanical modeling characterization of biological cells using microrobotics cell injection test bed

Content Provider	IEEE Xplore Digital Library
Author	Youhua Tan Dong Sun Wenhao Huang
Copyright Year	2009
Description	Author affiliation: Control and Mechatronics Group, Suzhou Research Institute of City University of Hong Kong and University of Science and Technology of China, China (Youhua Tan) \|\| Department of Manufacturing Engineering and Engineering Management, City University of Hong Kong, Kowloon, Hong Kong (Dong Sun) \|\| Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China (Wenhao Huang)
Abstract	Mechanical properties of biological cells play an important role in regulating cellular functions. Some micromanipulation methods have been reported in the literature to measure cell mechanics, but they are either high-costly or difficultly-operated. This paper presents our approach to use microrobotic cell injection technology as the test bed to characterize the mechanical properties of biological cells, by virtue of low cost and easy operation. By extending our previous work [41], we develop a mechanical model to interpret the mechanical responses during microinjection and extract the cells properties. Both finite element analysis and microinjection experiments are performed to verify the mechanical model. It is shown that the results obtained from the proposed mechanical model agree well with that obtained from finite element analysis and the experiments. Elastic moduli of zebrafish embryos at different developmental stages are characterized. This demonstrates not only the validity of the proposed model but also the fact that the microrobotic cell injection technology combining with the mechanical model can be used to characterize the mechanical properties of biological cells.
Starting Page	4337
Ending Page	4342
File Size	1312156
Page Count	6
File Format	PDF
ISBN	9781424438037
DOI	10.1109/IROS.2009.5354814
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-10-10
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biological system modeling Biological cells Cells (biology) Testing Mechanical factors Microinjection Finite element methods Mechanical variables measurement Costs Performance analysis
Content Type	Text
Resource Type	Article

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