NDLI: Magnetically modified polymeric microsorter for on-chip particle manipulations

Content Provider	IEEE Xplore Digital Library
Author	Yamanishi, Y. Sakuma, S. Onda, K. Arai, F.
Copyright Year	2008
Description	Author affiliation: Dept. of Bioeng. & Robot., Tohoku Univ., Sendai (Yamanishi, Y.; Sakuma, S.; Onda, K.; Arai, F.)
Abstract	The paper describes a novel non-contact manipulation system using an on-chip, magnetically driven micro-tool (MMT) rather than conventional biomanipulation by hand, which has a higher risk of contamination and lower success rate and repeatability. MMTs can sort particles individually, and have the unique feature that they can be installed directly in a microchannel (width = 150 mum), unlike conventional cell sorting systems. The drive unit was significantly downsized by amplifying the magnetic power using a permanent magnet. Lower power consumption could also be realized, because no energy is required to keep MMTs stationary at a particular position. Sorting was performed using real-time sensing images of microbeads, where the system successfully sorted beads of different sizes at switching speeds up to 18 Hz. The MMT developed in this study is unique with respect to its flexibility and biocompatibility; in addition, since the PDMS (polydimethylsiloxane) microchip is disposable, it can be applied to cell sorting without any risk of contamination. Potential fields of application of this technology include cloning techniques, which require sorting of oocytes with and without nuclei.
Starting Page	570
Ending Page	575
File Size	1625058
Page Count	6
File Format	PDF
ISBN	9781424420575
DOI	10.1109/IROS.2008.4650908
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-09-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sorting Microchannel Magnetic resonance imaging Iron Magnetic flux Force Switches
Content Type	Text
Resource Type	Article

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