NDLI: Toward targeted retinal drug delivery with wireless magnetic microrobots

Content Provider	IEEE Xplore Digital Library
Author	Dogangil, G. Ergeneman, O. Abbott, J.J. Pane, S. Hall, H. Muntwyler, S. Nelson, B.J.
Copyright Year	2008
Description	Author affiliation: Inst. of Robot. & Intell. Syst., ETH Zurich, Zurich (Dogangil, G.; Ergeneman, O.; Abbott, J.J.; Pane, S.; Hall, H.; Muntwyler, S.; Nelson, B.J.)
Abstract	Retinal vein occlusion is an obstruction of blood flow due to clot formation in the retinal vasculature, and is among the most common causes of vision loss. Currently, the most promising therapy involves injection of t-PA directly into small and delicate retinal vessels. This procedure requires surgical skills at the limits of human performance. In this paper, targeted retinal drug delivery with wireless magnetic microrobots is proposed. We focus on four fundamental issues involved in the development of such a system: biocompatible coating of magnetic microrobots, diffusion-based drug delivery, characterization of forces needed to puncture retinal veins, and wireless magnetic force generation. We conclude that targeted drug delivery with magnetic microrobots is feasible from an engineering perspective, and the idea should now be explored for clinical efficacy.
Starting Page	1921
Ending Page	1926
File Size	1034578
Page Count	6
File Format	PDF
ISBN	9781424420575
DOI	10.1109/IROS.2008.4650768
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-09-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Saturation magnetization Retina Force Coatings Veins Computer aided manufacturing
Content Type	Text
Resource Type	Article

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