NDLI: In-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice

Content Provider	IEEE Xplore Digital Library
Author	Al-Bataineh, O.M. Lweesy, K. Fraiwan, L.
Copyright Year	2012
Description	Author affiliation: Department of Biomedical Engineering, The Hashemite University, Zarqa 13115, Jordan (Al-Bataineh, O.M.) \|\| Department of Biomedical Engineering, Jordan University of Science and Technology, Irbid, Jordan (Lweesy, K.; Fraiwan, L.)
Abstract	A noninvasive transdermal delivery of insulin, using piston-shaped PZT ultrasound transducers, was suggested to reduce regular pain and suffering of type 1 diabetic patients. This alternative technique is intended to replace the long-term dependence on multiple subcutaneous insulin injections. Ten rabbits and ten mice were divided equally into four groups (two control groups and two exposure groups). The animals were anesthetized using a combination of Ketamine hydrochloride and Xylazine to produce temporarily diabetic animal models during the periods of the experiments. Animals in control groups did not receive ultrasound while animals in exposure groups received ultrasound mediated delivery of insulin for 5 and 10 minutes for mice and rabbits, respectively, during the continuous driving of the transducers. Sweep driving frequency signals were assigned to each exposure group with frequency range from 100 to 200 kHz. The signals were amplified to drive 30.0 mm diameter piston-shaped PZT transducers attached to the shaved skin of each exposed anesthetized animal. Custom made housing was used to create a reservoir to trap insulin between the face of the transducer and the exposed shaved abdomen areas of the animals during the delivery period. Blood glucose levels were measured depending on blood samples from the veins of the tails of the mice and the veins of the ears of the rabbits. These measurements were achieved using blood glucose meter every ten minutes for an hour starting from the delivery period. Over the recording period of 60 minutes, reduction of blood glucose levels compared to control groups were 67% and 50% for rabbits and mice, respectively. Ultrasound piston PZT transducers in the mid range frequency (100 to 200 kHz) were found feasible in transdermal insulin delivery in vivo using temporarily hyperglycemic rabbits and mice models.
Starting Page	504
Ending Page	507
File Size	898729
Page Count	4
File Format	PDF
ISBN	9781457719905
e-ISBN	9781457719912
DOI	10.1109/ICoBE.2012.6179069
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-02-27
Publisher Place	Malaysia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Rabbits Ultrasonic imaging Transducers Mice Skin Transdermal Delivery Insulin Ultrasound Noninvasive
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in