NDLI: Computational investigation of effects of UP state on EPSP in striatal Medium Spiny Neurons

Content Provider	IEEE Xplore Digital Library
Author	Rane, M. Shah, A. Sheth, S. Manchanda, R.
Copyright Year	2012
Description	Author affiliation: Biomedical Engineering Department, D. J. Sanghvi College of Engineering, Mumbai, India (Rane, M.; Shah, A.; Sheth, S.) \|\| Department of Biosciences and Bioengineering, Indian Institute of Technology, Mumbai, India (Manchanda, R.)
Abstract	Reward circuit is considered as the major site at which many drugs of abuse act. The nucleus accumbens (NAcc) plays an important role in the reward circuit and it constitutes the major subdivision of the ventral striatum. Medium Spiny Neuron (MSN), is the principal neuron of Nucleus accumbens (Nacc) and is known to possess bimodal behavior. Due to the bi modal behavior of the cell, there are significant discrepancies in the shape of the EPSP generated in the cell. A change in the active conductances of the cells causes a significant change in the nature of the EPSP generated. The effect of Sodium and Potassium channels is explored to understand their effect on MSN excitability.
Starting Page	562
Ending Page	566
File Size	1192260
Page Count	5
File Format	PDF
ISBN	9781457719905
e-ISBN	9781457719912
DOI	10.1109/ICoBE.2012.6178980
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-02-27
Publisher Place	Malaysia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nucleus accumbens Electric potential Bi modal behavior Neuroscience Integration Shape Firing Biological system modeling Calcium Neurons MSN
Content Type	Text
Resource Type	Article

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