NDLI: The Feedback Control of Glucose: On the road to type II diabetes

Content Provider	IEEE Xplore Digital Library
Author	Alvehag, K. Martin, C.
Copyright Year	2006
Abstract	This paper develops a mathematical model for the feedback control of glucose regulation in the healthy human being and is based on the work of Sorensen (1985). The proposed model serves as a starting point for modeling type II diabetes. Four agents - glucose and the three hormones insulin, glucagon, and incretins - are assumed to have an effect on glucose metabolism. By letting compartments represent anatomical organs, the model has a close resemblance to a real human body. Mass balance equations that account for blood flows, exchange between compartments, and metabolic sinks and sources are written, and these result in simultaneous differential equations that are solved numerically. The metabolic sinks and sources - removing or adding glucose, insulin, glucagon, and incretins - describe physiological processes in the body. These processes function as feedback control systems and have nonlinear behaviors. The results of simulations performed for three different clinical test types indicate that the model is successful in simulating intravenous glucose, oral glucose, and meals containing mainly carbohydrates
Starting Page	685
Ending Page	690
File Size	182132
Page Count	6
File Format	PDF
ISBN	1424401712
DOI	10.1109/CDC.2006.377192
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-12-13
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Feedback control Sugar Roads Diabetes Biological system modeling Humans Biochemistry Insulin Differential equations Mathematical model
Content Type	Text
Resource Type	Article

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