Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Szilagyi, S.M. Szilagyi, L. Hirsbrunner, B. |
| Copyright Year | 2013 |
| Description | Author affiliation: Univ. of Fribourg, Fribourg, Switzerland (Szilagyi, S.M.; Hirsbrunner, B.) || Budapest Univ. of Technol. & Econ., Budapest, Hungary (Szilagyi, L.) |
| Abstract | Aims: In the focus of this study stand the fibroblast cells that under physiological terms are providing structural support for the heart, but under pathophysiological conditions they can obstruct the pacemaker activity and the excitation spread function of the heart that may develop arrhythmia. Methods: We investigated the influence of high fibroblast level under several patho-physiological conditions. The simulation was performed on a 3D heart model, adopting a 0.25 mm spatial and 2 fJ.S temporal maximal resolution. In our simulation 25% volume of the normal cardiac tissue is occupied by fibroblast, and in presence of pathological cases or aging, the fibroblast cells accumulate up to 40%-95% volume. We employed the effect of cardio-myocyte death and laminar sheets. Results: In presence of 30%/35%/40%/45%/50% fibroblast in cardiac myocyte, the spread velocity of depolarization was obstructed by 3%/7%/JJ%/J5%/J9%, while regional inflammation and injures locally reduced the propagation speed of excitation by at least 20%. Tissue aging has reduced cardiac pacemaker activity and increased the possibility of irregular cardiac activity. Conclusion: High fibroblast levels not only detains significantly the spread of excitation, but it can obstruct the depolarization wave evolving cardiac arrhythmia. |
| Sponsorship | IEEE Eng. Med. Biol. Soc. |
| Starting Page | 45 |
| Ending Page | 48 |
| File Size | 307634 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781479908844 |
| ISSN | 2325887X |
| e-ISBN | 9781479908868 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2013-09-22 |
| Publisher Place | Spain |
| Access Restriction | Subscribed |
| Rights Holder | Creative Commons Attribution License 2.5 (CCAL) |
| Subject Keyword | Nonhomogeneous media Abstracts Computational modeling Fibroblasts Surgery Heart Biological system modeling |
| Content Type | Text |
| Resource Type | Article |
| Subject | Computer Science Cardiology and Cardiovascular Medicine |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|