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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Barbieri, R. Citi, L. Valenza, G. Guerrisi, M. Orsolini, S. Tessa, C. Diciotti, S. Toschi, N. |
| Copyright Year | 2013 |
| Description | Author affiliation: Univ. of Rome “Tor Vergata”, Rome, Italy (Guerrisi, M.) || Versilia Hosp., Viareggio, Italy (Tessa, C.) || Univ. of Florence, Florence, Italy (Orsolini, S.; Diciotti, S.) || Med. Sch., Massachusetts Gen. Hosp., Harvard Univ., Boston, MA, USA (Barbieri, R.; Citi, L.; Valenza, G.; Toschi, N.) |
| Abstract | Parkinson's disease (PD) has been reported to involve postganglionic sympathetic failure and, in 25% of patients, autonomic failure. In this work we investigate autonomic dynamics in PD using a novel methodology able to provide instantaneous estimates of the Lyapunov spectrum within a point process framework. Physiological signals were recorded from 10 healthy subjects and 9 cognitively preserved PD patients. We computed conventional heart rate variability (HRV) features as well as the full Lyapunov spectrum over 600s recordings at rest, and tested for significant group effects using a general linear model taking into account age and gender as nuisance covariates. Additionally, the discriminatory power of all features was tested by training a Support Vector Machine (SVM) classifier combined with recursive feature elimination (RFE) with a variable number of target features. The first and second Lyapunov exponents were significantly higher (p<;0.05) in PD patients vs. controls. No other HR V measure difered significantly between groups. The best classification performance (75% sensitivity, 8O% specificity, area under ROC curve O.8) was attained when instructing RFE to retain 2 features, where the algorithm selected the first and second Lyapunov exponents. Our results suggest that autonomic control in PD entails a preponderance of nonlinear, more unstable heartbeat dynamics with respect to controls. This could point to possible autonomic dysfunction which cannot be detected by conventional HRV measures. |
| Sponsorship | IEEE Eng. Med. Biol. Soc. |
| Starting Page | 89 |
| Ending Page | 92 |
| File Size | 699500 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781479908844 |
| ISSN | 2325887X |
| e-ISBN | 9781479908868 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2013-09-22 |
| Publisher Place | Spain |
| Access Restriction | Subscribed |
| Rights Holder | Creative Commons Attribution License 2.5 (CCAL) |
| Subject Keyword | Handheld computers Physiology Abstracts Biological system modeling Computational modeling Training Support vector machines |
| Content Type | Text |
| Resource Type | Article |
| Subject | Computer Science Cardiology and Cardiovascular Medicine |
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