NDLI: Antiarrhythmic drug effect analysis on a model of cardiac fiber

Content Provider	IEEE Xplore Digital Library
Author	Cimponeriu, A. Starmer, C.F. Bezerianos, A.
Copyright Year	2000
Description	Author affiliation: Dept. of Phys., Patras Univ., Greece (Cimponeriu, A.)
Abstract	Pharmacological treatment of cardiac arrhythmias still arises serious questions concerning both efficiency and safety. CAST failure as well as classification based on functional characteristics revealed the arrhythmogenic potential of both class I and class III agents, but failed to identify proarrhythmic mechanisms. These study, presents results from a model of the ventricle using a modified Luo-Rudy phase I cellular formulation. The model was used for studying both pro- and antiarrhythmic mechanisms of class I drugs. "Monitoring" was performed at cellular and cardiac fiber level in normal conditions and after drug delivery. For each specific arrhythmogenic mechanism, vulnerable parameters were investigated in order to detect the appropriate agent and ifs delivering requirements. Simulations revealed the link between the cellular antiarrhythmic potential and a proarrhythmic effect at the multicellular level.
Starting Page	517
Ending Page	520
File Size	387839
Page Count	4
File Format	PDF
ISBN	0780365577
ISSN	02766547
DOI	10.1109/CIC.2000.898572
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2000-09-24
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Displays Heart rate Protocols Propagation delay Physics Medical treatment Safety Condition monitoring Rhythm
Content Type	Text
Resource Type	Article

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