NDLI: Numerical simulations of cardiac dynamics. What can we learn from simple and complex models?

Content Provider	IEEE Xplore Digital Library
Author	Fenton, F.H.
Copyright Year	2000
Description	Author affiliation: Hofstra Univ., Hempstead, NY, USA (Fenton, F.H.)
Abstract	Modeling the electrical activity of the heart, and the complex signaling patterns that underlay dangerous arrhythmias such as tachycardia and fibrillation, requires a quantitative model of action potential propagation. At present, there exist detailed ionic models of the Hodgkin-Huxley form that accurately reproduce dynamical features of the action potential at a single cell level. However, such models are very time consuming in computer simulations. The authors show how simplified models can help on the study of cardiac arrhythmias. In particular, how breakup of spiral waves, believed as the dynamics underlying the transition from tachycardia to fibrillation, can occur as function of tissue size and shape. The authors also discuss some of the limitations in these models and some differences in dynamics between simple and complex models.
Starting Page	251
Ending Page	254
File Size	443476
Page Count	4
File Format	PDF
ISBN	0780365577
ISSN	02766547
DOI	10.1109/CIC.2000.898504
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2000-09-24
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Numerical simulation Spirals Mathematical model Heart Computer simulation Shape Cardiac tissue Cells (biology) Biomembranes Robustness
Content Type	Text
Resource Type	Article

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