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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Stice, P.J. Panitch, A. Muthuswamy, J. |
| Copyright Year | 2003 |
| Description | Author affiliation: Harrington Dept. of Bioeng., Arizona State Univ., Tempe, AZ, USA (Stice, P.J.; Panitch, A.; Muthuswamy, J.) |
| Abstract | The recording interface between neurons and an implanted microelectrode recording site is often compromised due to gliosis, rendering the implant nonfunctional under chronic conditions. The objective of this project is to design novel microelectrodes that will minimize gliosis under chronic implantation. We test the hypothesis that gliosis can be minimized or eliminated by reducing the cross-sectional area of the chronic implant. Current microelectrodes for recording chronic action potentials range from 25 /spl mu/m to 100 /spl mu/m or more in diameter. We fabricated neural implants by coating 12 /spl mu/m stainless steel microwires with polyglycolic acid (PGA), a biodegradable polymer, resulting in a final diameter of 25 /spl mu/m. Twelve rats were implanted with the PGA coated electrode on the left hemisphere in the somatosensory cortex and with the regular 25 /spl mu/m stainless microelectrode in the right hemisphere. The rat brains were perfused at 4 weeks after implantation and stained for glial fibrilliary acidic protein (GFAP) and microtubule associated protein-2 (MAP-2). The microelectrodes coated with PGA produced minimal gliosis compared to the conventional 25 /spl mu/m wire and other silicon based microelectrodes. We conclude that ultra-thin neural implants with minimum cross-sectional area coated with PGA will greatly improve the functionality of microelectrodes under chronic conditions. |
| Sponsorship | Whitaker Found |
| Starting Page | 1987 |
| Ending Page | 1989 |
| File Size | 169622 |
| Page Count | 3 |
| File Format | |
| ISBN | 0780377893 |
| ISSN | 1094687X |
| DOI | 10.1109/IEMBS.2003.1279846 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2003-09-17 |
| Publisher Place | Mexico |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Implants Microelectrodes Electronics packaging Proteins Neurons Rendering (computer graphics) Testing Coatings Steel Biodegradable materials |
| Content Type | Text |
| Resource Type | Article |
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