Please wait, while we are loading the content...
| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Becker, T.A. Kipke, D.R. |
| Copyright Year | 2003 |
| Description | Author affiliation: Dept. of Biomed. Eng., Michigan Univ., Ann Arbor, MI, USA (Becker, T.A.; Kipke, D.R.) |
| Abstract | ALGEL/sup /spl reg// (Neural Intervention Technologies, Ann Arbor, MI) has shown promise as a biocompatible and mechanically stable material when used as a dural sealant. ALGEL provides a suitable interface between the brain surface and cortical neural implants to help attain long-term neural recordings for over one year in laboratory animals. This paper investigates whether the ALGEL can cause abnormal neural activity or seizures when placed in contact with the motor cortex. Sixteen rats underwent craniotomy procedures and ALGEL and its reactive component, calcium chloride, were placed in contact with the cortex. The response of the animals was evaluated with electroencephalography (EEG) and clinical monitoring of behavior during controlled anesthesia for up to two hours post-application. ALGEL was compared with tranexamic acid (tAMCA), a synthetic fibrinolysis inhibitor that has been shown to cause epileptic seizures. tAMCA, at a dose of 100 mg/ml, showed marked paroxymal brain activity with associated and distinct episodes of jerk-correlated convulsive behaviors. However, various applications of ALGEL on the rat cortex showed no abnormal EEG signals and no episodes of jerk-correlated convulsive behaviors. ALGEL appears to be a safe and effective dural sealant that can be used alone or in combination with neural implants. |
| Sponsorship | Whitaker Found |
| Starting Page | 1972 |
| Ending Page | 1975 |
| File Size | 296797 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780377893 |
| ISSN | 1094687X |
| DOI | 10.1109/IEMBS.2003.1279836 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2003-09-17 |
| Publisher Place | Mexico |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Sealing materials Electroencephalography Brain Implants Animals Biological materials Laboratories Rats Calcium Monitoring |
| Content Type | Text |
| Resource Type | Article |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|