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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Naware, M. Thakor, N.V. Orth, R.N. Murari, K. Passeraub, P. |
| Copyright Year | 2003 |
| Description | Author affiliation: Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA (Naware, M.; Thakor, N.V.) |
| Abstract | A novel carbon sensor array has been microfabricated for the spatially distributed measurement of biological Nitric Oxide (NO). NO is intrinsically involved in a large number of brain injury states, like stroke, besides performing a bioregulatory role. The distributed measurement of biological NO signals is expected to be a very useful tool for researchers studying such phenomena. The array consists of microelectrode sites ordered as a 4/spl times/4 grid, and has been fabricated on a Si wafer using the photolithography of graphitic carbon. To provide selectivity to NO, in the presence of a large number of possible interfering ionic species, novel polymer coatings were used to modify the properties of the electrode array surface. First, a layer of the anion-blocking resin Nafion was spin-coated. The thickness-spin speed profile for Nafion was determined. The second layer consists of a combination of m-phenylenediamine and resorcinol which functions as a size filter. The resultant electrode array was selective and sensitive to NO at physiological levels, and was not responsive to analogous concentrations of dopamine, ascorbic acid and nitrite. Further, the sensors demonstrated very quick and short response times, making them suitable to measure fast, transient NO signals in the brain or vasculature. |
| Sponsorship | Whitaker Found |
| Starting Page | 1952 |
| Ending Page | 1955 |
| File Size | 328818 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780377893 |
| ISSN | 1094687X |
| DOI | 10.1109/IEMBS.2003.1279825 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2003-09-17 |
| Publisher Place | Mexico |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Sensor arrays Signal design Neurotransmitters Biosensors Electrodes Brain injuries Microelectrodes Lithography Polymer films Resins |
| Content Type | Text |
| Resource Type | Article |
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