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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Johnson, M. Overby, D. Ruberti, J. Freddo, T.F. Gong, H. |
| Copyright Year | 1999 |
| Description | Author affiliation: MIT, Cambridge, MA, USA (Johnson, M.) |
| Abstract | We present a hydrodynamic model of the aqueous outflow pathway that can, for the first time, account for the generation of outflow resistance based upon anatomical measurements. The hydraulic conductivity of the extracellular matrix in the juxtacanalicular connective tissue (JCT) is determined by combining advanced morphometric techniques with electron microscopy images taken using quick-freeze/deep-etch to preserve ultrastructural detail. A hydrodynamic interaction between pores of the endothelium of Schlemm's canal, breaks in the basement membrane, and this morphometrically-determined hydraulic conductivity lead to predictions that are consistent with experimentally-measured outflow resistances. |
| File Size | 97868 |
| File Format | |
| ISBN | 0780356748 |
| ISSN | 1094687X |
| DOI | 10.1109/IEMBS.1999.804485 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 1999-10-13 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Hydrodynamics Immune system Conductivity Extracellular Irrigation Biomembranes Electron microscopy Biomedical imaging Electrical resistance measurement Time measurement |
| Content Type | Text |
| Resource Type | Article |
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