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Content Provider | IEEE Xplore Digital Library |
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Author | Diamond, S.L. Sigurdson, S.L. Straubinger, N. |
Copyright Year | 1999 |
Description | Author affiliation: Dept. of Chem. Eng., Pennsylvania Univ., Philadelphia, PA, USA (Diamond, S.L.) |
Abstract | Bacterial survival in coagulated blood can cause complications associated with endocarditis or biomaterial infections. We report that during recalcification of diluted (1:5) citrated human whole blood, the killing activity toward E. coli decreased 90-fold after the addition of thrombin (1 U/ml) and CaCl/sub 2/ (50 mM). The killing activity in diluted citrated whole blood or plasma was Mg/sup 2+/-dependent and Ca/sup 2+/-independent (as well as heat-inactivated in plasma), demonstrating complement alternative pathway mediation of E. Coli lysis. Addition of calcium from 0 to 10 mM CaCl/sub 2/ in the presence of heparin (5 U/ml), PPACK (250 /spl mu/M), or hirudin (33 U/ml) to diluted citrated whole blood or plasma caused a dose-dependent inhibition of bacterial killing. Excess addition of fibrin or fibrinogen had no effect on bacterial survival in whole blood or plasma, with or without coagulation. Physiological levels of Ca/sup 2+/ (1 mM) had a cytoprotective effect that attenuated alternative pathway killing of E. coli. This previously unrecognized calcium modulation of the alternative pathway killing must be considered in the study of bacterial survival in coagulating blood. |
File Size | 101610 |
File Format | |
ISBN | 0780356748 |
ISSN | 1094687X |
DOI | 10.1109/IEMBS.1999.803928 |
Language | English |
Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Publisher Date | 1999-10-13 |
Publisher Place | USA |
Access Restriction | Subscribed |
Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Subject Keyword | Bacterial infections Blood Calcium Microorganisms Plasmas Coagulation Humans Inhibitors Laboratories Mediation |
Content Type | Text |
Resource Type | Article |
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