Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Lammertsma, A.A. |
| Copyright Year | 2012 |
| Description | Author affiliation: Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, Netherlands (Lammertsma, A.A.) |
| Abstract | Positron emission tomography (PET) is a tomographic imaging technique that allows for accurate non-invasive in vivo measurements of regional tissue function in man. It is the most selective and sensitive imaging modality able to measure molecular pathways and interactions in vivo at a picomolar level. PET is an important tool in drug development and can be used in different ways. Firstly, it is possible to label the drug itself with a positron emitter. This enables direct measurements of tissue drug concentrations, allowing for an assessment whether these concentrations are high enough for therapeutic purposes. An example is the uptake of labelled anti-cancer drugs in tumours, which can be compared with uptake in normal tissue (toxicity). Secondly, it is possible to measure perfusion or metabolism following or during treatment. Examples are measurements of tumour perfusion following anti-angiogenesis treatment and tumour glucose metabolism as a marker of response to chemotherapy. The latter is now accepted as a surrogate endpoint in trials with new anticancer drugs. Finally, receptor occupancy and enzyme inhibition can be measured using established radioligands for the molecular targets under investigation. The advantage of this approach is that it does not require novel radiochemistry or kinetic models. Receptor occupancy or enzyme activity can be measured as function of administered drug dose and biological clearance of the drug can be measured by performing scans at various times after drug administration. Both optimal dose and dosing regimen can be determined from studies with less than ten subjects. PET studies can be performed not only in patients, but also in animal models of disease. Since PET is non-invasive, it is possible to perform repeat measurements in the same animal. This is a major advantage as an experimental animal can be used as its own control. |
| Starting Page | 910 |
| Ending Page | 910 |
| File Size | 74664 |
| Page Count | 1 |
| File Format | |
| ISBN | 9781457718571 |
| ISSN | 19457928 |
| e-ISBN | 9781457718588 |
| DOI | 10.1109/ISBI.2012.6235698 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2012-05-02 |
| Publisher Place | Spain |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Positron emission tomography Drugs Biochemistry Tumors Animals In vivo drug development Positron Emission Tomography (PET) radiolabelling receptor occupancy clinical trials |
| Content Type | Text |
| Resource Type | Article |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|