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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Ersoy, I. Bunyak, F. Higgins, J.M. Palaniappan, K. |
| Copyright Year | 2012 |
| Description | Author affiliation: University of Missouri Columbia, Department of Computer Science, Columbia, MO 65201 (Ersoy, I.; Bunyak, F.; Palaniappan, K.) || Department of Systems Biology, Harvard Medical School, Boston, MA 02115 (Higgins, J.M.) |
| Abstract | Physiological properties of blood flow at the microvasculature scale can be measured by tracking the movement and density of red blood cells (RBCs). In this paper we propose a method for individual RBC segmentation to enable tracking and capturing dynamically varying bulk transport properties. RBCs have varying annular and disk like morphologies, and are often clustered into clumps that are difficult to segment using watershed-based methods. Edge profile active contours in combination with graph coloring based coupling (C-EPAC) are introduced as a robust approach to prevent merges between adjacent, clumped RBCs by modifying the active contour energy function to be sensitive to a specific edge profile and not just the magnitude as in the traditional methods. Explicit coupling is combined with graph coloring to efficiently compute the contour evolution using the fewest number of level sets to support high-throughput studies of RBC flow characterization under varying physiological conditions. |
| Starting Page | 748 |
| Ending Page | 751 |
| File Size | 938548 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781457718571 |
| ISSN | 19457928 |
| e-ISBN | 9781457718588 |
| DOI | 10.1109/ISBI.2012.6235656 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2012-05-02 |
| Publisher Place | Spain |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Active contours Level set Red blood cells Couplings Image edge detection Image segmentation cell tracking cell segmentation level set active contours red blood cells |
| Content Type | Text |
| Resource Type | Article |
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