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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Yafang Cheng Yetik, I.S. |
| Copyright Year | 2008 |
| Description | Author affiliation: Dept. of Electr. Eng., Illinois Inst. of Technol., Chicago, IL (Yafang Cheng; Yetik, I.S.) |
| Abstract | PET is an imaging modality widely used in areas such as oncology, neurology, cardiology and neuropsychology/cognitive neuro-science. Dynamic PET, in contrast to static PET, can identify temporal variations in the radiotracer concentration. Mathematical modeling of the tissue of interest in dynamic PET can be simplified using compartment models as a linear system where the time activity curve of a specific tissue is the convolution of the tracer concentration in the plasma and the impulse response of the tissue containing kinetic parameters. Since the arterial sampling of blood to acquire the value of the tracer concentration is invasive, blind identification to estimate both the blood input function and the kinetic parameters has recently drawn attention. Several methods have been developed for this purpose, but the effect of the estimated blood on the estimation of the kinetic parameters is not studied. In this paper, we present a mathematical model to compute the error in the kinetic parameter estimates caused by the error in estimation of the blood input function. Computer simulations show that analytical expressions we derive are sufficiently close to results obtained from optimization. Our findings are conceptually important to observe the effect of the blood function on kinetic parameter estimation, but also practically useful to evaluate various blind methods. |
| Starting Page | 1585 |
| Ending Page | 1588 |
| File Size | 136490 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424420025 |
| DOI | 10.1109/ISBI.2008.4541314 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2008-05-14 |
| Publisher Place | France |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Blood Parameter estimation Kinetic theory Positron emission tomography Mathematical model Computer errors Oncology Nervous system Cardiology Linear systems estimation of blood function Dynamic Positron emission tomography kinetic parameter estimation blind methods |
| Content Type | Text |
| Resource Type | Article |
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