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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Silberberg, Y.R. Felling, A.E. Yakubov, G.E. Crum, W.R. Hawkes, D.J. Horton, M.A. |
| Copyright Year | 2008 |
| Description | Author affiliation: London Centre for Nanotechnol. & Centre for NanoMedicine, Univ. Coll. London, London (Silberberg, Y.R.; Felling, A.E.) |
| Abstract | The living cell is under constant influence of mechanical forces from its environment. These forces affect many aspects of the cell's behaviour, including morphology, growth, cell differentiation, protein synthesis and cell death. In this study we show how mechanical stress perturbs the intracellular structures of the cell and induces mechanical responses. In order to correlate mechanical perturbations to cellular responses, we used a combined fluorescence-atomic force microscope (AFM) to produce nanomechanical perturbations while simultaneously tracking the real-time motion of fluorescently labelled mitochondria in live cells. Feature point tracking was then used to analyze and quantify the structural displacements. Following indentation from the AFM tip, the average mitochondrial displacement showed an increase of -40% in comparison to the natural movement. These results show how mitochondrial structures that are far away from the point of force (up to ~40 mum) are instantaneously affected by extracellular perturbations. |
| Starting Page | 1335 |
| Ending Page | 1338 |
| File Size | 428136 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424420025 |
| DOI | 10.1109/ISBI.2008.4541251 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2008-05-14 |
| Publisher Place | France |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Atomic force microscopy Particle tracking Fluorescence Nanobioscience Trajectory Cells (biology) Optical microscopy Extracellular Atomic measurements Educational institutions particle tracking Atomic Force Microscopy fluorescence microscopy mitochondria nanomechanics mechanotransduction |
| Content Type | Text |
| Resource Type | Article |
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