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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Raphisak, P. Schuckers, S.A.C. |
| Copyright Year | 2003 |
| Description | Author affiliation: Lane Dept. of Comput. Sci. & Electr. Eng., West Virginia Univ., WV, USA (Raphisak, P.; Schuckers, S.A.C.) |
| Abstract | A long-term experiment was conducted by the use of a doxorubicin rabbit model of heart failure. Heart failure was progressively induced in two groups of animals by weekly administrating doxorubicin in amount of 2 mg/kg and 4 mg/kg, respectively. Control animals were injected saline. The ECG was continuously recorded for three weeks prior to treatment and up to ten weeks post-treatment. In analysis, eleven time-domain and frequency-domain heart rate variability (HRV) parameters were computed for every usable 5-minute segment for the entire period of recordings. Karhunen-Loeve expansion was utilized to track the changes of HRV as heart failure develops. The concept is extracting basis components of pretreatment HRV by using singular value decomposition and determining change of these basis components in posttreatment HRV by observing its coefficients. The results show changes in coefficient values in treatment animals, while it remains unchanged in control animals. |
| Sponsorship | Schering Plough Becton Dickinson Boston Scientific Reva |
| Starting Page | 242 |
| Ending Page | 243 |
| File Size | 162222 |
| Page Count | 2 |
| File Format | |
| ISBN | 0780377672 |
| DOI | 10.1109/NEBC.2003.1216083 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2003-03-22 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Failure analysis Heart rate variability Rabbits Animals Electrocardiography Hafnium Matrix decomposition Computer science Cardiac arrest Cardiac disease |
| Content Type | Text |
| Resource Type | Article |
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