NDLI: Modulation of hemocoagulative response by lead nitrate

Content Provider	IEEE Xplore Digital Library
Author	Sohail, M.A. Kristol, D. Spillert, C.R. Arora, R.R.
Copyright Year	2003
Description	Author affiliation: New Jersey Inst. of Technol., Newark, NJ, USA (Sohail, M.A.; Kristol, D.)
Abstract	Introduction of a lead ion in the form of lead nitrate has been found to induce coagulopathy in human blood. A marked toxic action on the normal hemocoagulative mechanism, under a background of lead intoxication, is manifested through an increase of clotting time for lead treated blood. The in vitro study carried out with citrated human blood samples (n=12) utilized celite as a procoagulant in both the control samples and the lead treated blood samples. Various 500 /spl mu/l samples of blood were treated with varying molar concentrations of lead nitrate. As a substitute for the lead nitrate solution, the control was treated with 0.1% saline solution. It should be noted that at this concentration, saline solution does not alter the coagulation time of blood. Following the incubation of the samples for 10 min. at 37/spl deg/C, 200 /spl mu/l of blood was taken from each sample and recalcified by 20 /spl mu/l of 0.1 M CaCl/sub 2/ to initiate clotting for measuring the coagulation time. Results thus obtained indicated a direct correlation between Pb(NO/sub 3/)/sub 2/ addition and coagulation time for each sample. Furthermore, anticoagulant activity was shown to increase with higher concentrations of Pb(NO/sub 3/)/sub 2/.
Sponsorship	Schering Plough Becton Dickinson Boston Scientific Reva
Starting Page	189
Ending Page	190
File Size	103439
Page Count	2
File Format	PDF
ISBN	0780377672
DOI	10.1109/NEBC.2003.1216057
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-03-22
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Blood Lead Coagulation Humans Time measurement Instruments Temperature Diseases Medical treatment Proteins
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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