NDLI: Simulations of Voltage Transients Across Intracellular Mitochondrial Membranes Due to Nanosecond Electrical Pulses

Content Provider	IEEE Xplore Digital Library
Author	Hao Qiu Shu Xiao Joshi, R.P.
Copyright Year	1973
Abstract	Simulations to quantify the induction of transmembrane potentials across the mitochondrial membranes have been carried out, taking account of their irregular shape. Our results demonstrate that short (60 ns), high-intensity pulses have the capacity to create membrane potentials, while longer 600-ns pulses are not as effective. Also, the plasma membrane effects are always greater than those at the mitochondria, and that poration at the inner mitochondrial membrane is more difficult than at the outer mitochondrial membrane. In the shorter pulse range, geometric dependence is very pronounced, and so short pulses could be very effective in highly irregular shaped cells, such as neurons. Finally, bioeffects due to the longer 600-ns pulses as seen experimentally, is likely due to other (secondary) effects such as calcium inflow from the porated plasma membrane at the mitochondrial sites.
Sponsorship	IEEE Nuclear and Plasma Sciences Society
Starting Page	3113
Ending Page	3120
Page Count	8
File Size	2573524
File Format	PDF
ISSN	00933813
Volume Number	42
Issue Number	10
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biomembranes Plasmas Geometry Cells (biology) Conductivity Electric potential Mathematical model nanosecond electric pulse. Apoptosis implications electroporation mitochondrial membrane modeling nanosecond electric pulse
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Condensed Matter Physics

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