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Loss of telomeres in the progeny of human lymphocytes exposed to energetic heavy ions
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Cucinotta, F. A. George, K. Durante, M. |
| Copyright Year | 2006 |
| Description | We have used cross-species multi-color banding (RxFISH) combined with telomere FISH probes, to measure chromosomal aberrations in the progeny of human peripheral blood lymphocytes exposed to ionizing radiation. Accelerated iron particles (energy 1 GeV/nucleon) induced many more terminal deletions than the same dose of gamma-rays. We found that truncated chromosomes without telomeres could be transmitted for at least three cell cycles following exposure, and represented about 10% of all aberrations observed in the progeny of cells exposed to iron ions. High energy heavy ions generate the most significant health risk for human space exploration and the results suggest that telomere loss may be the leading mechanism for their high efficiency in the induction of late effects. |
| File Size | 249176 |
| Page Count | 13 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20080026202 |
| Archival Resource Key | ark:/13960/t20c9xh1x |
| Language | English |
| Publisher Date | 2006-01-01 |
| Access Restriction | Open |
| Subject Keyword | Aerospace Medicine Radiation Effects Mutations Heavy Ions Manned Space Flight Radiation Dosage Energetic Particles Telomeres Ionizing Radiation Biological Effects Bioastronautics Lymphocytes Risk Assessment Deoxyribonucleic Acid Genetics Space Exploration Chromosome Aberrations Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Article |
