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Dna damage signals and space radiation risk
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Cucinotta, Francis A. |
| Copyright Year | 2011 |
| Description | Space radiation is comprised of high-energy and charge (HZE) nuclei and protons. The initial DNA damage from HZE nuclei is qualitatively different from X-rays or gamma rays due to the clustering of damage sites which increases their complexity. Clustering of DNA damage occurs on several scales. First there is clustering of single strand breaks (SSB), double strand breaks (DSB), and base damage within a few to several hundred base pairs (bp). A second form of damage clustering occurs on the scale of a few kbp where several DSB?s may be induced by single HZE nuclei. These forms of damage clusters do not occur at low to moderate doses of X-rays or gamma rays thus presenting new challenges to DNA repair systems. We review current knowledge of differences that occur in DNA repair pathways for different types of radiation and possible relationships to mutations, chromosomal aberrations and cancer risks. |
| File Size | 9345 |
| Page Count | 1 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20110016229 |
| Archival Resource Key | ark:/13960/t5q869b98 |
| Language | English |
| Publisher Date | 2011-10-20 |
| Access Restriction | Open |
| Subject Keyword | Aerospace Medicine Mutations Physiological Effects Biological Effects X Rays Deoxyribonucleic Acid Extraterrestrial Radiation Radiation Damage Chromosome Aberrations Cancer Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Article |
