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Painting analysis of chromosome aberrations induced by energetic heavy ions in human cells
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Wu, Honglu |
| Copyright Year | 2006 |
| Description | FISH, mFISH, mBAND, telomere and centromere probes have been used to study chromosome aberrations induced in human cells exposed to low-and high-LET radiation in vitro. High-LET induced damages are mostly a single track effect. Unrejoined chromosome breaks (incomplete exchanges) and complex type aberrations were higher for high-LET. Biosignatures may depend on the method the samples are collected. Recent mBAND analysis has revealed more information about the nature of intra-chromosome exchanges. Whether space flight/microgravity affects radiation-induced chromosome aberration frequencies is still an open question. |
| File Size | 1157141 |
| Page Count | 25 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20060053352 |
| Archival Resource Key | ark:/13960/t9673dz44 |
| Language | English |
| Publisher Date | 2006-01-01 |
| Access Restriction | Open |
| Subject Keyword | Telomeres Heavy Ions Biomarkers Damage Microgravity In Vitro Methods and Tests Chromosomes Chromosome Aberrations Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Article |
