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Rbe of energetic iron ions for the induction of early and late chromosome aberrations in different cell types
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Hada, Megumi Kadhim, Munira Zhang, Ye Wu, Honglu Wilson, Bobby Yeshitla, Samrawit |
| Copyright Year | 2015 |
| Description | Numerous published studies have reported the Relative Biological Effectiveness (RBE) values for chromosome aberrations induced by charged particles of different LET. The RBE for chromosome aberrations in human lymphocytes exposed ex vivo has been suggested to show a similar relationship as the quality factor for cancer induction. Therefore, increased chromosome aberrations in the astronauts' white blood cells post long-duration missions are used to determine the biological doses from exposures to space radiation. However, the RBE value is known to be very different for different types of cancer. Previously, we reported that, even though the RBE for initial chromosome damages was high in human lymphocytes exposed to Fe ions, the RBE was significantly reduced after multiple cell divisions post irradiation. To test the hypothesis that RBE values for chromosome aberrations are cell type dependent, and different between early and late damages, we exposed human lymphocytes ex vivo, and human mammary epithelial cells in vitro to various charged particles. Chromosome aberrations were quantified using the samples collected at first mitosis post irradiation for initial damages, and the samples collected after multiple generations for the remaining or late arising aberrations. Results of the study suggested that the effectiveness of high-LET charged particles for late chromosome aberrations may be cell type dependent, even though the RBE values are similar for early damages. |
| File Size | 368118 |
| Page Count | 1 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20150001627 |
| Archival Resource Key | ark:/13960/t0ns5rn42 |
| Language | English |
| Publisher Date | 2015-01-13 |
| Access Restriction | Open |
| Subject Keyword | Space Radiation Aerospace Medicine Radiation Effects Peripheral Circulation Relative Biological Effectiveness Rbe Ferric Ions Blood Cells Mammary Glands Intravenous Procedures Bioastronautics Lymphocytes Astronauts Extraterrestrial Radiation In Vitro Methods and Tests Chromosome Aberrations Cancer Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Presentation |
