NDLI: Activation and regulation mechanisms of NOD-like receptors based on structural biology

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Year: 2023 Month: September Volume: 14

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Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages

SARS-CoV-2 variants Alpha, Beta, Delta and Omicron show a slower host cell interferon response compared to an early pandemic variant

Pyroptosis and respiratory diseases: A review of current knowledge

Efficacy, effectiveness, and safety of herpes zoster vaccine in the immunocompetent and immunocompromised subjects: A systematic review and network meta-analysis

A novel cuproptosis-related molecular pattern and its tumor microenvironment characterization in colorectal cancer

Editorial: DNA repair and immune response

Pathogenic variant c.1052T>A (p.Leu351Gln) in adenosine deaminase 2 impairs secretion and elevates type I IFN responsive gene expression

Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment

Vitamin C deficiency reveals developmental differences between neonatal and adult hematopoiesis

Safety and efficacy of fecal microbiota transplantation for autoimmune diseases and autoinflammatory diseases: A systematic review and meta-analysis

Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients

Downregulation of long noncoding RNA HCP5/miR-216a-5p/ZEB1 axis inhibits the malignant biological function of laryngeal squamous cell carcinoma cells

Systems biology and artificial intelligence analysis highlights the pleiotropic effect of IVIg therapy in autoimmune diseases with a predominant role on B cells and complement system

Metabolic-related gene pairs signature analysis identifies ABCA1 expression levels on tumor-associated macrophages as a prognostic biomarker in primary IDHWT glioblastoma

The human myocardium harbors a population of naive B-cells with a distinctive gene expression signature conserved across species

Genetic factors underlying tacrolimus intolerance after liver transplantation

Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response

Change in adverse event reporting following immunization of hepatitis B vaccine among infants between 2013 to 2020 before and after the vaccine administration law in China

Adipokines as potential biomarkers for type 2 diabetes mellitus in cats

SARS-CoV-2 antibody responses before and after a third dose of the BNT162b2 vaccine in Italian healthcare workers aged ≤60 years: One year of surveillance

Elevated serum C1q is an independent predictor of high residual platelet reactivity in CAD patients receiving clopidogrel therapy

Editorial: Next generation γδ T cell-based tumor immunotherapy

Gastrointestinal Talaromyces marneffei infection in a patient with AIDS: A case report and systematic review

Distinct spatial distribution and roles of Kupffer cells and monocyte-derived macrophages in mouse acute liver injury

Case report: Autoimmune nodopathy with concurrent serum and CSF IgG4 anti-neurofascin 155 antibodies

The OSE complotype and its clinical potential

Impact of adjuvant: Trivalent vaccine with quadrivalent-like protection against heterologous Yamagata-lineage influenza B virus

Reestablish immune tolerance in rheumatoid arthritis

Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma

Phosphate and IL-10 concentration as predictors of long-covid in hemodialysis patients: A Brazilian study

AIM2 as a putative target in acute kidney graft rejection

Foot-and-mouth disease virus non-structural protein 2B downregulates the RLR signaling pathway via degradation of RIG-I and MDA5

Neutrophil depletion in the pre-implantation phase impairs pregnancy index, placenta and fetus development

Sterile protection and transmission blockade by a multistage anti-malarial vaccine in the pre-clinical study

The role of the astrocyte in subarachnoid hemorrhage and its therapeutic implications

Sustained Infiltration of Neutrophils Into the CNS Results in Increased Demyelination in a Viral-Induced Model of Multiple Sclerosis

MSC-EVs transferring mitochondria and related components: A new hope for the treatment of kidney disease

Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency

Enlarged perivascular spaces, neuroinflammation and neurological dysfunction in NMOSD patients

miR-210-3p protects against osteoarthritis through inhibiting subchondral angiogenesis by targeting the expression of TGFBR1 and ID4

Early immunological responses to the mRNA SARS-CoV-2 vaccine in patients with neuromuscular disorders

Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers

An allergenic plant calmodulin from Artemisia pollen primes human DCs leads to Th2 polarization

Specific circulating neutrophils subsets are present in clinically stable adults with cystic fibrosis and are further modulated by pulmonary exacerbations

Novel peanut-specific human IgE monoclonal antibodies enable screens for inhibitors of the effector phase in food allergy

Decreased peripheral basophil counts in urticaria and mouse model of oxazolone-induced hypersensitivity, the latter suggesting basopenia reflecting migration to skin

The function of omega-3 polyunsaturated fatty acids in response to cadmium exposure

Independent and interactive effects of eye rubbing and atopy on keratoconus

Independent value of serum β-human chorionic gonadotropin in predicting early pregnancy loss risks in IVF/ICSI cycles

Understanding inborn errors of immunity: A lens into the pathophysiology of monogenic inflammatory bowel disease

Genetic susceptibility loci for Chlamydia trachomatis endometrial infection influence expression of genes involved in T cell function, tryptophan metabolism and epithelial integrity

Acute stress induces an inflammation dominated by innate immunity represented by neutrophils in mice

Identification and validation of ferroptosis-related lncRNA signature as a prognostic model for skin cutaneous melanoma

Comprehensive immune cell analysis of human menstrual-blood-derived stem cells therapy to concanavalin A hepatitis

Explainable artificial intelligence for precision medicine in acute myeloid leukemia

Persistent but dysfunctional mucosal SARS-CoV-2-specific IgA and low lung IL-1β associate with COVID-19 fatal outcome: A cross-sectional analysis

The causal relationship between neuromyelitis optica spectrum disorder and other autoimmune diseases

Genetic association of leukocyte telomere length with Graves’ disease in Biobank Japan: A two-sample Mendelian randomization study

The third dose of mRNA SARS-CoV-2 vaccines enhances the spike-specific antibody and memory B cell response in myelofibrosis patients

HLA Associations in pediatric autoimmune liver diseases: Current state and future research initiatives

Characterization of age-related immune features after autologous NK cell infusion: Protocol for an open-label and randomized controlled trial

The role of complement in nonalcoholic fatty liver disease

Knowledge mapping of targeted immunotherapy for myasthenia gravis from 1998 to 2022: A bibliometric analysis

(Not) Home alone: Antigen presenting cell – T Cell communication in barrier tissues

Immunological study of COVID-19 vaccine candidate based on recombinant spike trimer protein from different SARS-CoV-2 variants of concern

Oral manifestations serve as potential signs of ulcerative colitis: A review

Peripheral blood marker of residual acute leukemia after hematopoietic cell transplantation using multi-plex digital droplet PCR

Single Domain Antibody application in bacterial infection diagnosis and neutralization

Landscape of circulating metabolic fingerprinting for keloid

Investigating the influence of breastfeeding on asthma in children under 12 years old in the UK Biobank

Cannabidiol modulates expression of type I IFN response genes and HIV infection in macrophages

Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense

Identification of cross-talk pathways and ferroptosis-related genes in periodontitis and type 2 diabetes mellitus by bioinformatics analysis and experimental validation

On the clinical relevance of using complete high-resolution HLA typing for an accurate interpretation of posttransplant immune-mediated graft outcomes

P2X7 purinergic receptor plays a critical role in maintaining T-cell homeostasis and preventing lupus pathogenesis

In ovo model in cancer research and tumor immunology

Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers – ORCHESTRA project

Case report: Bilateral panuveitis resembling Vogt-Koyanagi-Harada disease after second dose of BNT162b2 mRNA COVID-19 vaccine

Type 2 autoimmune hepatitis: Genetic susceptibility

Interleukin-17 as a potential therapeutic target for chronic pain

Blood DNA methylation marks discriminate Chagas cardiomyopathy disease clinical forms

Plasma proteome responses in zebrafish following λ-carrageenan-Induced inflammation are mediated by PMN leukocytes and correlate highly with their human counterparts

Identification and validation of a 17-gene signature to improve the survival prediction of gliomas

Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants

Associations of microbial and indoleamine-2,3-dioxygenase-derived tryptophan metabolites with immune activation in healthy adults

The role of a key transcription factor PU.1 in autoimmune diseases

Analysis of chromatin data supports a role for CD14+ monocytes/macrophages in mediating genetic risk for juvenile idiopathic arthritis

An immunogenic cell death-related regulators classification patterns and immune microenvironment infiltration characterization in intracranial aneurysm based on machine learning

Evaluating the role of IDO1 macrophages in immunotherapy using scRNA-seq and bulk-seq in colorectal cancer

Single cell meta-analysis of EndMT and EMT state in COVID-19

Genomics and transcriptomics reveal new molecular mechanism of vibriosis resistance in fish

Modulation of urelumab glycosylation separates immune stimulatory activity from organ toxicity

Simultaneous genotyping for human platelet antigen systems and HLA-A and HLA-B loci by targeted next-generation sequencing

cGAS/STING and innate brain inflammation following acute high-fat feeding

PD-1 inhibition plus platinum-based chemotherapy (PBC) or PBC alone in the first-line treatment of locally advanced or metastatic pulmonary lymphoepithelioma-like carcinoma

External validation of biomarkers for immune-related adverse events after immune checkpoint inhibition

Assessment of plasma Catestatin in COVID-19 reveals a hitherto unknown inflammatory activity with impact on morbidity-mortality

Antithrombin activity levels for predicting long-term outcomes in the early phase of isolated traumatic brain injury

Cuproptosis regulator-mediated patterns associated with immune inﬁltration features and construction of cuproptosis-related signatures to guide immunotherapy

Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation

Comparative efficacy and safety of JAK inhibitors as monotherapy and in combination with methotrexate in patients with active rheumatoid arthritis: A systematic review and meta-analysis

Combination treatment of radiofrequency ablation and peptide neoantigen vaccination: Promising modality for future cancer immunotherapy

Construction and internal validation of a predictive model for risk of gastrointestinal bleeding in children with abdominal Henoch-Schönlein purpura: A single-center retrospective case-control study

PTPRD/PTPRT mutation as a predictive biomarker of immune checkpoint inhibitors across multiple cancer types

Signature construction and molecular subtype identification based on cuproptosis-related genes to predict the prognosis and immune activity of patients with hepatocellular carcinoma

Malnutrition leads to increased inflammation and expression of tuberculosis risk signatures in recently exposed household contacts of pulmonary tuberculosis

Correlation of antigen-specific immune response with disease severity among COVID-19 patients in Bangladesh

miR-aculous new avenues for cancer immunotherapy

Mycobacterial acyl carrier protein suppresses TFEB activation and upregulates miR-155 to inhibit host defense

The impact of platelets on pulmonary microcirculation throughout COVID-19 and its persistent activating factors

Coagulation parameters predict COVID-19-related thrombosis in a neural network with a positive predictive value of 98%

Atypical hemolytic uremic syndrome triggered by mRNA vaccination against SARS-CoV-2: Case report

CAR-T cell therapy for hematological malignancies: Limitations and optimization strategies

LncRNA NCAL1 potentiates natural killer cell cytotoxicity through the Gab2-PI3K-AKT pathway

Central role of PD-L1 in cardioprotection resulting from P2Y4 nucleotide receptor loss

Cross-reactivity between vaccine antigens from the chitin deacetylase protein family improves survival in a mouse model of cryptococcosis

Innate immune checkpoint inhibitor resistance is associated with melanoma sub-types exhibiting invasive and de-differentiated gene expression signatures

Single-cell sequencing reveals effects of chemotherapy on the immune landscape and TCR/BCR clonal expansion in a relapsed ovarian cancer patient

The effect of tai chi intervention on NLRP3 and its related antiviral inflammatory factors in the serum of patients with pre-diabetes

Association between immune-related adverse events and the efficacy of PD-1 inhibitors in advanced esophageal cancer

Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation

Identification and validation of the common pathogenesis and hub biomarkers in Hirschsprung disease complicated with Crohn’s disease

The cytokine network in acute myeloid leukemia

HLA allele-specific expression: Methods, disease associations, and relevance in hematopoietic stem cell transplantation

Preoperative systemic inflammatory response index predicts long-term outcomes in type B aortic dissection after endovascular repair

SLE classification criteria: Science-based icons or algorithmic distractions – an intellectually demanding dilemma

Transcriptional states of CAR-T infusion relate to neurotoxicity – lessons from high-resolution single-cell SOM expression portraying

Prognostic value of programmed cell death ligand-1 expression in patients with bladder urothelial carcinoma undergoing radical cystectomy: A meta-analysis

Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro

Metabolomics-based investigation of SARS-CoV-2 vaccination (Sinovac) reveals an immune-dependent metabolite biomarker

Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota

Basophils activation of patients with chronic spontaneous urticaria in response to C5a despite failure to respond to IgE-mediated stimuli

Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction

Predictive mutation signature of immunotherapy benefits in NSCLC based on machine learning algorithms

N-3 polyunsaturated fatty acids may affect the course of COVID-19

Deregulated hyaluronan metabolism in the tumor microenvironment drives cancer inflammation and tumor-associated immune suppression

Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis

COVID-19 vaccine hesitancy and associated factors among infertile couples undergoing assisted reproductive treatment

Identification of four immune subtypes in locally advanced rectal cancer treated with neoadjuvant chemotherapy for predicting the efficacy of subsequent immune checkpoint blockade

SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling

Practical aspects of chimeric antigen receptor T-cell administration: From commercial to point-of-care manufacturing

Time evolution of cytokine profiles associated with mortality in COVID-19 hospitalized patients

Using personalized prognosis in the treatment of relapsing multiple sclerosis: A practical guide

Dysregulated autoantibodies targeting vaso- and immunoregulatory receptors in Post COVID Syndrome correlate with symptom severity

Editorial: Characterisation, functions and roles of antigen-specific regulatory T cells in health and disease

3’UTR of SARS-CoV-2 spike gene hijack host miR-296 or miR-520h to disturb cell proliferation and cytokine signaling

Recent advances in CAR-T cells therapy for colorectal cancer

Structure of a new glycyrrhiza polysaccharide and its immunomodulatory activity

CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma

Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile

Expression of the phagocytic receptors αMβ2 and αXβ2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells

Systematic pattern analyses of Vδ2+ TCRs reveal that shared “public” Vδ2+ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status

Screening and identification of tissue-infiltrating immune cells and genes for patients with emphysema phenotype of COPD

The immune microenvironment landscape shows treatment-specific differences in rectal cancer patients

Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

MicroRNAs as diagnostic biomarkers for Tuberculosis: A systematic review and meta- analysis

Mechanism and strategies of immunotherapy resistance in colorectal cancer

NKp46+ natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection

Case report: Complete remission of bone metastasis from renal cell carcinoma in histopathological examination after treatment with immune checkpoint inhibitors

Pattern recognition receptor CD14 gene polymorphisms in alcohol use disorder patients and its Influence on liver disease susceptibility

Editorial: The impact of the DNA damage response on anti-tumor immunity

Machine learning reveals two heterogeneous subtypes to assist immune therapy based on lipid metabolism in lung adenocarcinoma

Excretory/secretory proteins inhibit host immune responses by downregulating the TLR4/NF-κB/MAPKs signaling pathway: A possible mechanism of immune evasion in parasitic nematode Haemonchus contortus

Not enough by half: NFAT5 haploinsufficiency in two patients with Epstein-Barr virus susceptibility

Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation

Sex hormones, intestinal inflammation, and the gut microbiome: Major influencers of the sexual dimorphisms in obesity

Whole-cell vaccine candidates induce a protective response against virulent Acinetobacter baumannii

Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages

Exploring the risk factors for ischemic cerebrovascular disease in systemic lupus erythematosus: A single-center case-control study

Efficacy of immune checkpoint inhibitor therapy in EGFR mutation-positive patients with NSCLC and brain metastases who have failed EGFR-TKI therapy

OX40 agonist stimulation increases and sustains humoral and cell-mediated responses to SARS-CoV-2 protein and saRNA vaccines

Identifying hub circadian rhythm biomarkers and immune cell infiltration in rheumatoid arthritis

NLRP3: Role in ischemia/reperfusion injuries

The clinical value of indirect immunofluorescence for screening anti-rods and rings antibodies: A retrospective study of two centers in China

Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients

Immunogenic cell death related risk model to delineate ferroptosis pathway and predict immunotherapy response of patients with GBM

Acid external and internal environment exchange the Oreochromis niloticus tissue immune gene expression compared to the mouse macrophage polarization model

Case Report: Successful engraftment of allogeneic hematopoietic stem cells using CAR-T cell therapy as the conditioning regimen in R/R Ph+ B cell acute lymphoblastic leukemia

Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina

Single-cell sequencing of PBMC characterizes the altered transcriptomic landscape of classical monocytes in BNT162b2-induced myocarditis

Neoadjuvant therapy alters the immune microenvironment in pancreatic cancer

Identification of hub biomarkers and immune cell infiltration characteristics of polymyositis by bioinformatics analysis

Analysis of two cooperating antibodies unveils immune pressure imposed on HIV Env to elicit a V3-glycan supersite broadly neutralizing antibody lineage

Editorial: The emerging role of metabolism and metabolic-related receptors on neutrophil extracellular traps (NET) formation

Hemp seed significantly modulates the endocannabinoidome and produces beneficial metabolic effects with improved intestinal barrier function and decreased inflammation in mice under a high-fat, high-sucrose diet as compared with linseed

The regulation and potential roles of m6A modifications in early embryonic development and immune tolerance at the maternal-fetal interface

Communication is key: Innate immune cells regulate host protection to helminths

Cuproptosis-related gene FDX1 expression correlates with the prognosis and tumor immune microenvironment in clear cell renal cell carcinoma

Comparative analysis of the neutralizing activity against SARS-CoV-2 Wuhan-Hu-1 strain and variants of concern: Performance evaluation of a pseudovirus-based neutralization assay

A multi-faceted approach to sex and gender equity in solid organ transplantation: The Women in Transplantation Initiative of The Transplantation Society

Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem cell transplantation for severe combined immunodeficiency

A cell-based assay for detection of anti-fibrillarin autoantibodies with performance equivalent to immunoprecipitation

The potential risk factors of early-onset post-stroke depression from immuno-inflammatory perspective

Low baseline IFN-γ response could predict hospitalization in COVID-19 patients

Organoids and microphysiological systems: Promising models for accelerating AAV gene therapy studies

What is the optimal duration of immune checkpoint inhibitors in malignant tumors?

Synthetic MRI in the detection and quantitative evaluation of sacroiliac joint lesions in axial spondyloarthritis

Immunological characterization and function analysis of L-type lectin from spotted knifejaw, Oplegnathus punctatus

Selective miRNA inhibition in CD8+ cytotoxic T lymphocytes enhances HIV-1 specific cytotoxic responses

SARS-CoV-2 IgG spike protein antibody response in mRNA-1273 Moderna® vaccinated patients on maintenance immunoapheresis – a cohort study

Public awareness should be raised on a crucial but neglected factor for COVID-19 vaccination

Teleost fish IgM+ plasma-like cells possess IgM-secreting, phagocytic, and antigen-presenting capacities

POP1 inhibits MSU-induced inflammasome activation and ameliorates gout

Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury

CAR-T manufactured from frozen PBMC yield efficient function with prolonged in vitro production

Integration of single-cell RNA sequencing and bulk RNA sequencing to reveal an immunogenic cell death-related 5-gene panel as a prognostic model for osteosarcoma

Construction of a nomogram to predict the survival of metastatic gastric cancer patients that received immunotherapy

Severity of SARS-CoV-2 infection is associated with high numbers of alveolar mast cells and their degranulation

Nonalcoholic fatty liver disease in inflammatory arthritis: Relationship with cardiovascular risk

Immune repertoire and evolutionary trajectory analysis in the development of diabetic nephropathy

Basiliximab for the therapy of acute T cell–mediated rejection in kidney transplant recipient with BK virus infection: A case report

Prediction model for the pretreatment evaluation of mortality risk in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with interstitial lung disease

A novel T-cell proliferation-associated regulator signature pre-operatively predicted the prognostic of bladder cancer

Kynurenine serves as useful biomarker in acute, Long- and Post-COVID-19 diagnostics

Kinetics of vaccine-induced neutralizing antibody titers and estimated protective immunity against wild-type SARS-CoV-2 and the Delta variant: A prospective nationwide cohort study comparing three COVID-19 vaccination protocols in South Korea

Frontline workers: Mediators of mucosal immunity in community acquired pneumonia and COVID-19

Editorial: From microbial immunology to microbial therapeutics via targeted delivery technology

(NZW × BXSB) F1 male mice: An unusual, severe and fatal mouse model of lupus erythematosus

Real-world effectiveness and protection of SARS-CoV-2 vaccine among patients hospitalized for COVID-19 in Xi’an, China, December 8, 2021, to January 20, 2022: A retrospective study

Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s disease

CD56-negative NK cells: Frequency in peripheral blood, expansion during HIV-1 infection, functional capacity, and KIR expression

Exploration of immune response mechanisms in cadmium and copper co-exposed juvenile golden cuttlefish (Sepia esculenta) based on transcriptome profiling

Cuproptosis depicts tumor microenvironment phenotypes and predicts precision immunotherapy and prognosis in bladder carcinoma

Construction and validation of nomograms based on the log odds of positive lymph nodes to predict the prognosis of lung neuroendocrine tumors

Targeting myeloid villains in the treatment with immune checkpoint inhibitors in gastrointestinal cancer

Target organ expression and biomarker characterization of chemokine CCL21 in systemic sclerosis associated pulmonary arterial hypertension

Cytokines and chemokines: The vital role they play in herpes simplex virus mucosal immunology

Targeting the innate repair receptor axis via erythropoietin or pyroglutamate helix B surface peptide attenuates hemolytic-uremic syndrome in mice

Evaluation of anifrolumab safety in systemic lupus erythematosus: A meta-analysis and systematic review

Extracellular vesicles: A new diagnostic biomarker and targeted drug in osteosarcoma

The integration of single-cell sequencing, TCGA, and GEO data analysis revealed that PRRT3-AS1 is a biomarker and therapeutic target of SKCM

Vitamin D, exercise, and immune health in athletes: A narrative review

GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis

An EMT-based risk score thoroughly predicts the clinical prognosis, tumor immune microenvironment and molecular subtypes of bladder cancer

Eosinophilic gastrointestinal disorders in patients with inborn errors of immunity: Data from the USIDNET registry

A real-time GPU-accelerated parallelized image processor for large-scale multiplexed fluorescence microscopy data

Unique profile of predominant CCR5-tropic in CRF07_BC HIV-1 infections and discovery of an unusual CXCR4-tropic strain

Glutaminolysis and CD4+ T-cell metabolism in autoimmunity: From pathogenesis to therapy prospects

Case Report: Paroxysmal hyperhidrosis as an initial symptom in a patient with anti-LGI1 encephalitis

IgE receptor responsiveness of basophils in chronic inducible urticaria

COVID-19 in unvaccinated patients with inborn errors of immunity—polish experience

Diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation

Decreased TCF1 and BCL11B expression predicts poor prognosis for patients with chronic lymphocytic leukemia

Phenotypic characterization of Ghanaian P. falciparum clinical isolates reveals a homogenous parasite population

The yin-yang of immunity: Immune dysregulation in myelodysplastic syndrome with different risk stratification

Protective role of host complement system in Aspergillus fumigatus infection

Biological drugs for systemic lupus erythematosus or active lupus nephritis and rates of infectious complications. Evidence from large clinical trials

Modeling the effect of environmental cytokines, nutrient conditions and hypoxia on CD4+ T cell differentiation

Association between gene polymorphisms in the cyclophosphamide metabolism pathway with complications after haploidentical hematopoietic stem cell transplantation

Coexistence of multiple anti-neuronal antibodies in autoimmune encephalitis in China: A multi-center study

Discovery and characterization of SARS-CoV-2 reactive and neutralizing antibodies from humanized CAMouseHG mice through rapid hybridoma screening and high-throughput single-cell V(D)J sequencing

Serum hepatitis B virus large and medium surface proteins as novel tools for predicting HBsAg clearance

Reaction of SARS-CoV-2 antibodies with other pathogens, vaccines, and food antigens

Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma

Novel brain PET imaging agents: Strategies for imaging neuroinflammation in Alzheimer’s disease and mild cognitive impairment

T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy

Maternal siRNA silencing of placental SAA2 mitigates preterm birth following intrauterine inflammation

Role of cross-reactivity in cellular immune targeting of influenza A M158-66 variant peptide epitopes

A novel cuproptosis-related subtypes and gene signature associates with immunophenotype and predicts prognosis accurately in neuroblastoma

Causes of death and conditional survival estimates of long-term lung cancer survivors

Cilia-related gene signature in the nasal mucosa correlates with disease severity and outcomes in critical respiratory syncytial virus bronchiolitis

A novel neutrophil extracellular trap signature to predict prognosis and immunotherapy response in head and neck squamous cell carcinoma

Therapeutic strategies for gastric cancer targeting immune cells: Future directions

Lymphomas in cartilage-hair hypoplasia – A case series of 16 patients reveals advanced stage DLBCL as the most common form

Membrane attack complexes, endothelial cell activation, and direct allorecognition

PD-1 inhibitors plus anti-angiogenic therapy with or without intensity-modulated radiotherapy for advanced hepatocellular carcinoma: A propensity score matching study

Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning

Genetic analysis of CFH and MCP in Egyptian patients with immune-complex proliferative glomerulonephritis

Herpes simplex virus type 2 inhibits TNF-α-induced NF-κB activation through viral protein ICP22-mediated interaction with p65

Outcome of SARS-CoV-2 infection among patients with common variable immunodeficiency and a matched control group: A Danish nationwide cohort study

Investigation of the efficacy and safety of cryoablation and intra-arterial PD-1 inhibitor in patients with advanced disease not responding to checkpoint inhibitors: An exploratory study

Characterization of cancer-related fibroblasts (CAF) in hepatocellular carcinoma and construction of CAF-based risk signature based on single-cell RNA-seq and bulk RNA-seq data

Immunogenicity of two COVID-19 vaccines used in India: An observational cohort study in health care workers from a tertiary care hospital

Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target

Editorial: The importance of Th17/Treg imbalance in asthma and COPD development and progression

Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells

Impact of vaccination on hospitalization and mortality from COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience

Safety and efficacy of probiotic supplementation in 8 types of inflammatory arthritis: A systematic review and meta-analysis of 34 randomized controlled trials

Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities

Mannose inhibits Plasmodium parasite growth and cerebral malaria development via regulation of host immune responses

Validation of the X-ray microtomography in the assessment of duodenal morphometry and surface area in celiac disease

Highly different effects of phage therapy and antibiotic therapy on immunological responses of chickens infected with Salmonella enterica serovar Typhimurium

Effect of stereotactic radiotherapy on immune microenvironment of lung cancer

Assessment of type I interferon signatures in undifferentiated inflammatory diseases: A Japanese multicenter experience

Immunogenicity and safety of the booster BNT162b2 vaccine in patients with axial spondyloarthritis treated with biological disease-modifying drugs

Lymphocyte–C-reactive protein ratio can differentiate disease severity of COVID-19 patients and serve as an assistant screening tool for hospital and ICU admission

Regulation of gut microbiota-bile acids axis by probiotics in inflammatory bowel disease

Comprehensive characterisation of immunogenic cell death in melanoma revealing the association with prognosis and tumor immune microenvironment

Desmoglein compensation hypothesis fidelity assessment in Pemphigus

Cuproptosis-related modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of kidney renal clear cell carcinoma

Altered distribution and function of NK-cell subsets lead to impaired tumor surveillance in JAK2V617F myeloproliferative neoplasms

Applications of machine learning in tumor-associated macrophages

Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases

Mendelian randomization analysis reveals causal effects of food intakes on inflammatory bowel disease risk

Bacteroides fragilis ameliorates Cronobacter malonaticus lipopolysaccharide-induced pathological injury through modulation of the intestinal microbiota

The emerging roles of interstitial macrophages in pulmonary fibrosis: A perspective from scRNA-seq analyses

Primary immunodeficiencies in Bulgaria - achievements and challenges of the PID National Expert Center

Process development and preclinical evaluation of a major Plasmodium falciparum blood stage vaccine candidate, Cysteine-Rich Protective Antigen (CyRPA)

Could AMPs and B-cells be the missing link in understanding periodontitis?

Blocking LAIR1 signaling in immune cells inhibits tumor development

Case report: Immunoadsorption therapy for anti-caspr1 antibody-associated nodopathy

Effects of low-calorie and different weight-maintenance diets on IgG glycome composition

Single-cell RNA sequencing of CSF reveals neuroprotective RAC1+ NK cells in Parkinson’s disease

Gallbladder microbiota in early vertebrates provides evolutionary insights into mucosal homeostasis

Prognostic characteristics and clinical response to immunotherapy targeting programmed cell death 1 for patients with advanced gastric cancer with liver metastases

Update on mosquito bite reaction: Itch and hypersensitivity, pathophysiology, prevention, and treatment

Liver mesenchymal stem cells are superior inhibitors of NK cell functions through differences in their secretome compared to other mesenchymal stem cells

Complement activation in Hidradenitis suppurativa: Covert low-grade inflammation or innocent bystander?

Cumulative IgE-levels specific for respiratory allergens as biomarker to predict efficacy of anti-IgE-based treatment of severe asthma

Evidence of maternal transfer of antigen-specific antibodies in serum and breast milk to infants at high-risk of S. pneumoniae and H. influenzae disease

Physical activity and risk of multiple sclerosis: A Mendelian randomization study

5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis

Maternal gut microbiota during pregnancy and the composition of immune cells in infancy

Editorial: Understanding anti-trypanosomatid immune responses: The key to developing protective strategies against them

Extracellular vesicles derived from Trichinella Spiralis larvae promote the polarization of macrophages to M2b type and inhibit the activation of fibroblasts

Prognostic value of TIGIT in East Asian patients with solid cancers: A systematic review, meta-analysis and pancancer analysis

Editorial: Insights in T Cell Biology: 2021

The impact of pre-transplant donor specific antibodies on the outcome of kidney transplantation – Data from the Swiss transplant cohort study

Single-cell RNA sequencing reveals the role of immune-related autophagy in spinal cord injury in rats

Experimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease

Corrigendum: Innate lymphoid cells are required to induce airway hyperreactivity in a murine neutrophilic asthma model

T cell receptor excision circles are potential predictors of survival in adult allogeneic hematopoietic stem cell transplantation recipients with acute myeloid leukemia

Neither COVID-19, nor cryopreservation, prevented allogeneic product infusion: A report from the National Marrow Donor Program

Enforcing GLUT3 expression in CD8+ T cells improves fitness and tumor control by promoting glucose uptake and energy storage

A novel CARD11 germline mutation in a Chinese patient of B cell expansion with NF-κB and T cell anergy (BENTA) and literature review

Editorial: Impact of microbiome on gut mucosal immunity in health and disease

Identification of immune-related endoplasmic reticulum stress genes in sepsis using bioinformatics and machine learning

Common variable immunodeficiency in two kindreds with heterogeneous phenotypes caused by novel heterozygous NFKB1 mutations

Case report: Two PD-L1 positive unresectable advanced pancreatic carcinoma patients with microsatellite stability achieved R0 resection after PD-1 antibody plus chemotherapy as a successful downstaging therapy: A report of two cases

P2Y6 receptor-mediated signaling amplifies TLR-induced pro-inflammatory responses in microglia

Optic nerve head: A gatekeeper for vitreous infectious insults?

Canakinumab for the treatment of autoinflammatory very early onset- inflammatory bowel disease

Disease predisposition of human leukocyte antigen class II genes influences the gut microbiota composition in patients with primary biliary cholangitis

A rapid turnaround gene panel for severe autoinflammation: Genetic results within 48 hours

Identification and validation of autophagy-related gene expression for predicting prognosis in patients with idiopathic pulmonary fibrosis

Editorial: The placenta, fetomaternal tolerance and beyond: A tribute to Sir Peter Medawar on the 60th anniversary of his Nobel Prize

A prediction model for acute kidney injury in adult patients with hemophagocytic lymphohistiocytosis

Association of gestational diabetes mellitus and negative modulation of the specific humoral and cellular immune response against Toxoplasma gondii

Research progress of risk factors and early diagnostic biomarkers of gout-induced renal injury

Defining the role of neutrophils in the lung during infection: Implications for tuberculosis disease

The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation

IFN-γ transforms the transcriptomic landscape and triggers myeloid cell hyperresponsiveness to cause lethal lung injury

Strong inflammatory signatures in the neutrophils of PAMI syndrome

IL12 immune therapy clinical trial review: Novel strategies for avoiding CRS-associated cytokines

High-progesterone environment preserves T cell competency by evading glucocorticoid effects on immune regulation

IL-10 partly mediates the ability of MSC-derived extracellular vesicles to attenuate myocardial damage in experimental metabolic renovascular hypertension

Engineered cord blood megakaryocytes evade killing by allogeneic T-cells for refractory thrombocytopenia

Complement and endothelial cell activation in COVID-19 patients compared to controls with suspected SARS-CoV-2 infection: A prospective cohort study

Emerging roles of circular RNAs in tuberculosis

Safety and immunogenicity of 3 doses of BNT162b2 and CoronaVac in children and adults with inborn errors of immunity

Saliva is suitable for SARS-CoV-2 antibodies detection after vaccination: A rapid systematic review

Human chorionic gonadotropin promotes murine Treg cells and restricts pregnancy-harmful proinflammatory Th17 responses

From protein-protein interactions to immune modulation: Therapeutic prospects of targeting Neuropilin-1 in high-grade glioma

Proline metabolism reprogramming of trained macrophages induced by early respiratory infection combined with allergen sensitization contributes to development of allergic asthma in childhood of mice

HBV immune tolerance of HBs-transgenic mice observed through parabiosis with WT mice

Rethinking detection of pre-existing and intervening Plasmodium infections in malaria clinical trials

Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases

miR-150-5p and XIST interaction controls monocyte adherence: Implications for osteoarthritis therapy

A catalog of the genetic causes of hereditary angioedema in the Canary Islands (Spain)

You are what you eat: How to best fuel your immune system

Transcriptional programming of immunoregulatory responses in human Langerhans cells

Intracellular survival of Streptococcus pneumoniae in human alveolar macrophages is augmented with HIV infection

Multi-omics analysis reveals the effects of microbiota on oral homeostasis

Immunological risk factors for sepsis-associated delirium and mortality in ICU patients

Grouper TRIM23 exerts antiviral activity against iridovirus and nodavirus

Systemic immune responses after ischemic stroke: From the center to the periphery

NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma

Bifidobacterium breve intervention combined with environmental enrichment alleviates cognitive impairment by regulating the gut microbiota and microbial metabolites in Alzheimer’s disease mice

Versican enrichment predicts poor prognosis and response to adjuvant therapy and immunotherapy in gastric cancer

Effect of FOXP2 transcription factor on immune infiltration of thyroid cancer and its potential clinical value

Induction of T cell exhaustion by JAK1/3 inhibition in the treatment of alopecia areata

Alterations of m6A RNA methylation regulators contribute to autophagy and immune infiltration in primary Sjögren’s syndrome

The impact of CoronaVac on the neutralization breadth and magnitude of the antibody response to SARS-CoV-2 viruses

Circulating CD81-expressing extracellular vesicles as biomarkers of response for immune-checkpoint inhibitors in advanced NSCLC

Potential of conserved antigenic sites in development of universal SARS-like coronavirus vaccines

Challenges in the diagnosis of periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome in developing countries—A decade of experience from North India

The NLRP3 inflammasome as a new target in respiratory disorders treatment

Characterization of the immune system of Ellegaard Göttingen Minipigs - An important large animal model in experimental medicine

Csf2ra deletion attenuates acute lung injuries induced by intratracheal inoculation of aerosolized ricin in mice

Improving the immunomodulatory function of mesenchymal stem cells by defined chemical approach

Detection of rare autoreactive T cell subsets in patients with pemphigus vulgaris

The need for more holistic immune profiling in next-generation SARS-CoV-2 vaccine trials

Dynamic changes of cytokine profiles and virological markers during 48 weeks of entecavir treatment for HBeAg-positive chronic hepatitis B

The role of extracellular traps in ischemia reperfusion injury

Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19

Bacteroides fragilis outer membrane vesicles preferentially activate innate immune receptors compared to their parent bacteria

Identification of cuproptosis -related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in prostate cancer

Increased sIL-2Rα leads to obstruction of IL-2 biological function and Treg cells differentiation in SLE patients via binding to IL-2

Proteomic insights into SARS-CoV-2 infection mechanisms, diagnosis, therapies and prognostic monitoring methods

Comprehensive analyses of a tumor-infiltrating lymphocytes-related gene signature regarding the prognosis and immunologic features for immunotherapy in bladder cancer on the basis of WGCNA

Epitranscriptome profiling of spleen mRNA m6A methylation reveals pathways of host responses to malaria parasite infection

Comprehensive analysis of m6A/m5C/m1A-related gene expression, immune infiltration, and sensitivity of antineoplastic drugs in glioma

A risk signature based on necroptotic-process-related genes predicts prognosis and immune therapy response in kidney cell carcinoma

Comprehensive analysis of cellular senescence-related genes in the prognosis, tumor microenvironment, and immunotherapy/chemotherapy of clear cell renal cell carcinoma

Pyroptosis in development, inflammation and disease

Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood

Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications

Tuning Rex rules HTLV-1 pathogenesis

Intestinal immune responses to commensal and pathogenic protozoa

Calcitonin gene-related peptide is a potential autoantigen for CD4 T cells in type 1 diabetes

Reduction of blood C-reactive protein concentration complements the resolution of sputum bacillary load in patients on anti-tuberculosis therapy

OncomiRs as noncoding RNAs having functions in cancer: Their role in immune suppression and clinical implications

Immune landscape and risk prediction based on pyroptosis-related molecular subtypes in triple-negative breast cancer

Durable disease control and refractory bullous pemphigoid after immune checkpoint inhibitor discontinuation in metastatic renal cell carcinoma: A case report

The short-term and long-term effects of intranasal mesenchymal stem cell administration to noninflamed mice lung

Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity

Integrated analysis of intestinal microbiota and metabolomic reveals that decapod iridescent virus 1 (DIV1) infection induces secondary bacterial infection and metabolic reprogramming in Marsupenaeus japonicus

TMBcat: A multi-endpoint p-value criterion on different discrepancy metrics for superiorly inferring tumor mutation burden thresholds

Prospects of animal models and their application in studies on adaptive immunity to SARS-CoV-2

Melatonin pretreatment on exosomes: Heterogeneity, therapeutic effects, and usage

Adenosine signaling: Optimal target for gastric cancer immunotherapy

Targeting 4-1BB for tumor immunotherapy from bench to bedside

Regulation of CIRP by genetic factors of SP1 related to cold sensitivity

Unraveling the viral dark matter through viral metagenomics

Can exercise attenuate the negative effects of long COVID syndrome on brain health?

Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and disease

Research into the biological differences and targets in lung cancer patients with diverse immunotherapy responses

Telomere-related gene risk model for prognosis and drug treatment efficiency prediction in kidney cancer

Isolation of an escape-resistant SARS-CoV-2 neutralizing nanobody from a novel synthetic nanobody library

Bioinformatics and systems biology approach to identify the pathogenetic link of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Immunogenicity and safety of two-dose SARS-CoV-2 vaccination via different platforms in kidney transplantation recipients

An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis

Peritumoral tertiary lymphoid structure and tumor stroma percentage predict the prognosis of patients with non-metastatic colorectal cancer

Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity

Serine protease PRSS23 drives gastric cancer by enhancing tumor associated macrophage infiltration via FGF2

New insight into DAVF pathology—Clues from meningeal immunity

The expanding impact of T-regs in the skin

SEMA: Antigen B-cell conformational epitope prediction using deep transfer learning

Activation and regulation mechanisms of NOD-like receptors based on structural biology

Exploration of the underlying biological differences and targets in ovarian cancer patients with diverse immunotherapy response

Increased platelet activation and platelet-inflammasome engagement during chikungunya infection

Instantaneous death risk, conditional survival and optimal surgery timing in cervical fracture patients with ankylosing spondylitis: A national multicentre retrospective study

Cardiovascular risk factors: The effects of ageing and smoking on the immune system, an observational clinical study

Identification and validation of key molecules associated with humoral immune modulation in Parkinson’s disease based on bioinformatics

Site-specific N-glycosylation characterization of micro monoclonal immunoglobulins based on EThcD-sceHCD-MS/MS

Isolation of a cytolytic subpopulation of extracellular vesicles derived from NK cells containing NKG7 and cytolytic proteins

Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development

Sphingolipids, mycobacteria and host: Unraveling the tug of war

Single-cell RNA sequencing combined with whole exome sequencing reveals the landscape of the immune pathogenic response to chronic mucocutaneous candidiasis with STAT1 GOF mutation

CSE/H2S ameliorates colitis in mice via protection of enteric glial cells and inhibition of the RhoA/ROCK pathway

The paradoxical role of MDSCs in inflammatory bowel diseases: From bench to bedside

Case report: Refractory intestinal Behçet’s syndrome successfully treated with tofacitinib: A report of four cases

T cell receptor repertoire analysis in HTLV-1-associated diseases

Tissue-specific pathway activities: A retrospective analysis in COVID-19 patients

IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RA

A novel cuproptosis-related prognostic lncRNA signature for predicting immune and drug therapy response in hepatocellular carcinoma

Case report: Rare persistent complete donor chimerism and GVHD following micro-transplantation from HLA haplotype homozygous donors

Frequency of positive antiphospholipid antibodies in pregnant women with SARS-CoV-2 infection and impact on pregnancy outcome: A single-center prospective study on 151 pregnancies

Case report: Pneumonia with clinical symptoms precedes imaging evidence after immune checkpoint inhibitors combined with radiotherapy in lung squamous cell cancer

Macrophage activation syndrome in adults: Characteristics, outcomes, and therapeutic effectiveness of etoposide-based regimen

A novel genomic instability-derived lncRNA signature to predict prognosis and immune characteristics of pancreatic ductal adenocarcinoma

Case Report: Treatment for steroid-refractory immune-related myocarditis with tofacitinib

Autoantibodies in the pathogenesis of idiopathic inflammatory myopathies: Does the endoplasmic reticulum stress response have a role?

A cytokine/PTX3 prognostic index as a predictor of mortality in sepsis

A combined analysis of bulk and single-cell sequencing data reveals that depleted extracellular matrix and enhanced immune processes co-contribute to fluorouracil beneficial responses in gastric cancer

Serum MUC5AC protein levels are correlated with the development and severity of connective tissue disease-associated pulmonary interstitial lesions

Autoantibodies during infectious diseases: Lessons from malaria applied to COVID-19 and other infections

The role of mucosal-associated invariant T cells in visceral leishmaniasis

CyTOF analysis identifies unusual immune cells in urine of BCG-treated bladder cancer patients

Radiotherapy improves the outcomes of immunotherapy with Sintilimab in non-small-cell lung cancer: A real-world analysis

Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment

COVID-19 patients exhibit unique transcriptional signatures indicative of disease severity

Association between SII and hepatic steatosis and liver fibrosis: A population-based study

A new personalized vaccine strategy based on inducing the pyroptosis of tumor cells in vivo by transgenic expression of a truncated GSDMD N-terminus

The role of neuroimmune and inflammation in pediatric uremia-induced neuropathy

Life factors acting on systemic lupus erythematosus

Case report: Anti-NMDA receptor encephalitis manifesting as rapid weight loss and abnormal movement disorders with alternating unilateral ptosis and contralateral limb tremor

Marek’s disease virus-specific T cells proliferate, express antiviral cytokines but have impaired degranulation response

Biomarkers of related driver genes predict anti-tumor efficacy of immune checkpoint inhibitors

Mechanisms of tumor resistance to immune checkpoint blockade and combination strategies to overcome resistance

Temperature induces metabolic reprogramming in fish during bacterial infection

Clec7a expression in inflammatory macrophages orchestrates progression of acute kidney injury

Blau syndrome: Lessons learned in a tertiary care centre at Chandigarh, North India

Landscape of prognosis and immunotherapy responsiveness under tumor glycosylation-related lncRNA patterns in breast cancer

Harnessing invariant natural killer T cells to control pathological inflammation

Role of complement C1q/C3-CR3 signaling in brain injury after experimental intracerebral hemorrhage and the effect of minocycline treatment

Bifidobacterium animalis KV9 and Lactobacillus vaginalis FN3 alleviated β-lactoglobulin-induced allergy by modulating dendritic cells in mice

New insights into CAR T cell-mediated killing of tumor cells

Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma

Tumor necrosis factor receptor regulation of peripheral node addressin biosynthetic components in tumor endothelial cells

Long-term prognostic value of inflammatory biomarkers for patients with acute heart failure: Construction of an inflammatory prognostic scoring system

Newborn screening for severe combined immunodeficiency: The results of the first pilot TREC and KREC study in Ukraine with involving of 10,350 neonates

Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function

Largemouth bass (Micropterus salmoides) exhibited better growth potential after adaptation to dietary cottonseed protein concentrate inclusion but experienced higher inflammatory risk during bacterial infection

Influence of graft composition in patients with hematological malignancies undergoing ATG-based haploidentical stem cell transplantation

Surface Display of porcine circovirus type 2 antigen protein cap on the spores of bacillus subtilis 168: An effective mucosal vaccine candidate

D-tagatose protects against oleic acid-induced acute respiratory distress syndrome in rats by activating PTEN/PI3K/AKT pathway

Aging-related features predict prognosis and immunotherapy efficacy in hepatocellular carcinoma

Identification of novel B-1 transitional progenitors by B-1 lymphocyte fate-mapping transgenic mouse model Bhlhe41dTomato-Cre

Identification and characterization of the pathogenic potential of phenol-soluble modulin toxins in the mouse commensal Staphylococcus xylosus

V-Set and immunoglobulin domain containing (VSIG) proteins as emerging immune checkpoint targets for cancer immunotherapy

m6A methylation regulators as predictors for treatment of advanced urothelial carcinoma with anti-PDL1 agent

Prospect of research hotspots in prevention and treatment of diseases based on intestinal microbiome

Protective effect of tertiary lymphoid structures against hepatocellular carcinoma: New findings from a genetic perspective

Development of a standardized and validated flow cytometry approach for monitoring of innate myeloid immune cells in human blood

Circulating pyruvate is a potent prognostic marker for critical COVID-19 outcomes

MCPggaac haplotype is associated with poor graft survival in kidney transplant recipients with de novo thrombotic microangiopathy

Anti-DFS70 antibodies in systemic lupus erythematosus: Prevalence in a large Chinese cohort and an unexpected association with anti-dsDNA antibodies by a long-term follow-up

NOD-like receptors in asthma

Acute exercise mobilizes NKT-like cells with a cytotoxic transcriptomic profile but does not augment the potency of cytokine-induced killer (CIK) cells

The multifaceted roles of common gut microbiota in immune checkpoint inhibitor-mediated colitis: From mechanism to clinical application

Development of a novel hypoxia-immune–related LncRNA risk signature for predicting the prognosis and immunotherapy response of colorectal cancer

Research hotspot and trend analysis in the diagnosis of inflammatory bowel disease: A machine learning bibliometric analysis from 2012 to 2021

Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging

Cardiotoxicity of immune checkpoint inhibitors: A frequency network meta-analysis

Safety of autologous freshly expanded mesenchymal stromal cells for the treatment of graft-versus-host disease

Utilizing mast cells in a positive manner to overcome inflammatory and allergic diseases

Editorial: Type III interferons: Emerging roles beyond antiviral barrier defense

Mesenchymal stromal cells induced regulatory B cells are enriched in extracellular matrix genes and IL-10 independent modulators

Defining and targeting patterns of T cell dysfunction in inborn errors of immunity

Th17-cells in depression: Implication in multiple sclerosis

Durability of clinical and immunologic responses to extended low-dose interleukin-2 therapy in patients with refractory chronic graft-versus-host disease

Epstein-Barr Virus and multiple sclerosis in a Spanish cohort: A two-years longitudinal study

Reactogenicity and immunogenicity of the second COVID-19 vaccination in patients with inborn errors of immunity or mannan-binding lectin deficiency

Neutrophil extracellular traps in fungal infections: A seesaw battle in hosts

Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2

A novel immune cell signature for predicting osteosarcoma prognosis and guiding therapy

Immunogenicity profiling and distinct immune response in liver transplant recipients vaccinated with SARS-CoV-2 inactivated vaccines

The role of the complement system in kidney glomerular capillary thrombosis

Combinatorial suicide gene strategies for the safety of cell therapies

SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applications

Discovery of the first PD-1 ligand encoded by a pathogen

Inborn errors of immunity and related microbiome

Editorial: Immune responses and immune mechanisms triggered by snake and scorpion venoms

Plasma-derived exosomal mRNA profiles associated with type 1 diabetes mellitus

Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections

C-reactive protein, immunothrombosis and venous thromboembolism

Refined polysaccharide from Dendrobium devonianum resists H1N1 influenza viral infection in mice by activating immunity through the TLR4/MyD88/NF-κB pathway

The Euroflow PID Orientation Tube in the diagnostic workup of primary immunodeficiency: Daily practice performance in a tertiary university hospital

Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infection

HLAII peptide presentation of infliximab increases when complexed with TNF

Case report: Novel treatment regimen for enterovirus encephalitis in SCID

Rumen and fecal microbiota profiles associated with immunity of young and adult goats

Global alteration of colonic microRNAome landscape associated with inflammatory bowel disease

A radiogenomics biomarker based on immunological heterogeneity for non-invasive prognosis of renal clear cell carcinoma

Composition and regulation of the immune microenvironment of salivary gland in Sjögren’s syndrome

Identification of cuproptosis-related subtypes, cuproptosis-related gene prognostic index in hepatocellular carcinoma

Changes in macrophage-like cells characterized by en face optical coherence tomography after retinal stroke

Efficacy, immunogenicity and safety of COVID-19 vaccines in older adults: a systematic review and meta-analysis

SP-A binding to the SARS-CoV-2 spike protein using hybrid quantum and classical in silico modeling and molecular pruning by Quantum Approximate Optimization Algorithm (QAOA) Based MaxCut with ZDOCK

A protective role of HTLV-1 gp46-specific neutralizing and antibody-dependent cellular cytotoxicity-inducing antibodies in progression to adult T-cell leukemia (ATL)

Corrigendum: Targeting myeloid checkpoint molecules in combination with antibody therapy: A novel anti-cancer strategy with IgA antibodies?

Novel macrophage-related gene prognostic index for glioblastoma associated with M2 macrophages and T cell dysfunction

The emerging roles of piezo1 channels in animal models of multiple sclerosis

Bibliometric analysis of global research trends on pyroptosis in lung disease

SARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeability

Human differentiated eosinophils release IL-13 in response to IL-33 stimulation

Neoadjuvant immune checkpoint inhibitor in combination with chemotherapy or chemoradiotherapy in resectable esophageal cancer: A systematic review and meta-analysis

Crosstalk between dendritic cells and regulatory T cells: Protective effect and therapeutic potential in multiple sclerosis

Combining autophagy and immune characterizations to predict prognosis and therapeutic response in lung adenocarcinoma

Single-cell RNA-seq uncovered hemocyte functional subtypes and their differentiational characteristics and connectivity with morphological subpopulations in Litopenaeus vannamei

Benzophenone-3 and antinuclear antibodies in U.S. adolescents and adults ages 12-39 years

Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment

The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers

A comprehensive review of BBV152 vaccine development, effectiveness, safety, challenges, and prospects

Diet, microbiota, and the mucus layer: The guardians of our health

M2-like tumor-associated macrophage-related biomarkers to construct a novel prognostic signature, reveal the immune landscape, and screen drugs in hepatocellular carcinoma

Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during Aeromonas Hydrophila infection in grass carp (Ctenopharyngodon Idella)

The diagnosis of immune-related pancreatitis disguised as multifocal lesions on MRI by endoscopic ultrasound-guided fine-needle biopsy: A case report

Capillary leak syndrome following COVID-19 vaccination: Data from the European pharmacovigilance database Eudravigilance

The immune system as a system of relations

T cell responses to control fungal infection in an immunological memory lens

The pyroptosis-related gene signature predicts prognosis and indicates the immune microenvironment status of chronic lymphocytic leukemia

Association between germ-line HLA and immune-related adverse events

FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization

The regulation of ISG20 expression on SARS-CoV-2 infection in cancer patients and healthy individuals

Comparison between HIV self-testing and facility-based HIV testing approach on HIV early detection among men who have sex with men: A cross-sectional study

Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

An integrated bioinformatic investigation of mitochondrial energy metabolism genes in colon adenocarcinoma followed by preliminary validation of CPT2 in tumor immune infiltration

Antitumor effects of fecal microbiota transplantation: Implications for microbiome modulation in cancer treatment

Macrophages and neutrophils express IFNλs in granulomas from Mycobacterium tuberculosis-infected nonhuman primates

SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling

CD1d-independent NK1.1+ Treg cells are IL2-inducible Foxp3+ T cells co-expressing immunosuppressive and cytotoxic molecules

The peripheral and decidual immune cell profiles in women with recurrent pregnancy loss

Antibody-mediated cell depletion therapies in multiple sclerosis

Single-cell transcriptome analysis reveals T-cell exhaustion in denosumab-treated giant cell tumor of bone

Durable antibody and effector memory T cell responses in breastmilk from women with SARS-CoV-2

Immune-related gene signature associates with immune landscape and predicts prognosis accurately in patients with Wilms tumour

PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish

Could vitamin D supplementation play a role against COVID-19?

Circulating immune-complexes of IgG/IgM bound to B2-glycoprotein-I associated with complement consumption and thrombocytopenia in antiphospholipid syndrome

Immunoregulation and clinical significance of neutrophils/NETs-ANGPT2 in tumor microenvironment of gastric cancer

CXCL13 is elevated in inflammatory bowel disease in mice and humans and is implicated in disease pathogenesis

Integrated single-cell RNA-seq analysis identifies immune heterogeneity associated with KRAS/TP53 mutation status and tumor-sideness in colorectal cancers

Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from a lethal SARS-CoV-2 infection

Vascular homeostasis in atherosclerosis: A holistic overview

The oxygen carrier M101 alleviates complement activation, which may be beneficial for donor organ preservation

Tissue-resident memory T cells in chronic liver diseases: Phenotype, development and function

A clinical practice guideline for the screening and assessment of enthesitis in patients with spondyloarthritis

Manipulation of tissue factor-mediated basal PAR-2 signalling on macrophages determines sensitivity for IFNγ responsiveness and significantly modifies the phenotype of murine DTH

Non-cytotoxic functions of CD8 T cells: “repentance of a serial killer”

Case report: Understanding the impact of persistent tissue-localization of SARS-CoV-2 on immune response activity via spatial transcriptomic analysis of two cancer patients with COVID-19 co-morbidity

Corrigendum: The cholesterol-binding sequence in monomeric C-reactive protein binds to the SARS-CoV-2 spike receptor-binding domain and blocks interaction with Angiotensin-converting enzyme 2

Development of a screening score for Hemophagocytic Lymphohistiocytosis among pediatric patients with acute infection of Epstein-Barr virus

Ligand-based CAR-T cell: Different strategies to drive T cells in future new treatments

Cytokines as an important player in the context of CAR-T cell therapy for cancer: Their role in tumor immunomodulation, manufacture, and clinical implications

Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy

Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein

Vitamin D metabolism pathway polymorphisms are associated with efficacy and safety in patients under anti-PD-1 inhibitor therapy

Innate immune evasion by alphaviruses

The monocyte-to-osteoclast transition in rheumatoid arthritis: Recent findings

IL36G is associated with cutaneous antiviral competence in psoriasis

Cigarette smoke exposure reduces hemorrhagic shock induced circulatory dysfunction in mice with attenuated glucocorticoid receptor function

Effectiveness and safety of Belimumab combined with standard therapy in severe active lupus nephritis requiring kidney replacement therapy: A case report and literature review

Corrigendum: Effects of dietary mannan oligosaccharides on non-specific immunity, intestinal health, and antibiotic resistance genes in Pacific White Shrimp Litopenaeus vannamei

Immunoprofiling of monocytes in STAT1 gain-of-function chronic mucocutaneous candidiasis

T cell interaction with activated endothelial cells primes for tissue-residency

Regulation of T-independent B-cell responses by microRNA-146a

Autologous blood extracellular vesicles and specific CD4+ T-cell co-activation

Clinicopathological features and individualized treatment of kidney involvement in B-cell lymphoproliferative disorder

Role of RGC-32 in multiple sclerosis and neuroinflammation – few answers and many questions

Identification of diagnostic mRNA biomarkers in whole blood for ankylosing spondylitis using WGCNA and machine learning feature selection

Function and mechanism of histone β-hydroxybutyrylation in health and disease

HDL metabolism and functions impacting on cell cholesterol homeostasis are specifically altered in patients with abdominal aortic aneurysm

Booster dose of COVID-19 mRNA vaccine does not increase risks of myocarditis and pericarditis compared with primary vaccination: New insights from the vaccine adverse event reporting system

Immune Effects of Macrophages in Rheumatoid Arthritis: A Bibliometric Analysis From 2000 to 2021

The prognostic impact of previously infectious complications on allogeneic hematopoietic stem cell transplantation for patients with severe aplastic anemia: A single-center, retrospective study

Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants

How far are the new wave of mRNA drugs from us? mRNA product current perspective and future development

Identification of ST3GAL5 as a prognostic biomarker correlating with CD8+ T cell exhaustion in clear cell renal cell carcinoma

Treatment of aggressive T-cell lymphoma/leukemia with anti-CD4 CAR T cells

Role of N-Glycosylation in FcγRIIIa interaction with IgG

Visualization of macrophage subsets in the development of the fetal human inner ear

Andrographolide promote the growth and immunity of Litopenaeus vannamei, and protects shrimps against Vibrio alginolyticus by regulating inflammation and apoptosis via a ROS-JNK dependent pathway

Bacterial outer membrane vesicles as a candidate tumor vaccine platform

Unveiling the molecular features, relevant immune and clinical characteristics of SIGLEC15 in thyroid cancer

Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis

The efficacy of immune checkpoint inhibitors in advanced EGFR-Mutated non-small cell lung cancer after resistance to EGFR-TKIs: Real-World evidence from a multicenter retrospective study

Obesity induced gut dysbiosis contributes to disease severity in an animal model of multiple sclerosis

Intrahepatic activated leukocyte cell adhesion molecule induces CD6highCD4+ T cell infiltration in autoimmune hepatitis

The rabbit as an animal model to study innate immunity genes: Is it better than mice?

Factors associated with neutralizing antibody levels induced by two inactivated COVID-19 vaccines for 12 months after primary series vaccination

Exercise for osteoporosis: A literature review of pathology and mechanism

CARD9 deficiency predisposing chromoblastomycosis: A case report and comparative transcriptome study

Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria

How to place the duality of specific MMP-9 inhibition for treatment of inflammatory bowel diseases into clinical opportunities?

Bcl-3 regulates the function of Th17 cells through raptor mediated glycolysis metabolism

Maturation of circulating Ly6ChiCCR2+ monocytes by mannan-MOG induces antigen-specific tolerance and reverses autoimmune encephalomyelitis

Current progress and future perspectives of neoadjuvant anti-PD-1/PD-L1 therapy for colorectal cancer

Immune disruptions and night shift work in hospital healthcare professionals: The intricate effects of social jet-lag and sleep debt

Complement-mediated serum bactericidal activity of antibodies elicited by the Shigella sonnei GMMA vaccine in adults from a shigellosis-endemic country: Exploratory analysis of a Phase 2a randomized study

Differences in systemic and mucosal SARS-CoV-2 antibody prevalence in a prospective cohort of Dutch children

A specific immune signature for predicting the prognosis of glioma patients with IDH1-mutation and guiding immune checkpoint blockade therapy

Integrating peripheral blood and brain transcriptomics to identify immunological features associated with Alzheimer’s disease in mild cognitive impairment patients

Hepatic iNKT cells produce type 2 cytokines and restrain antiviral T cells during acute hepacivirus infection

Case Report: Susceptibility to viral infections and secondary hemophagocytic lymphohistiocytosis responsive to intravenous immunoglobulin as primary manifestations of adenosine deaminase 2 deficiency

Effect of Angelica polysaccharide on mouse myeloid-derived suppressor cells

SNAI1-dependent upregulation of CD73 increases extracellular adenosine release to mediate immune suppression in TNBC

Case report: A persistently expanded T cell response in an exceptional responder to radiation and atezolizumab for metastatic non-small cell lung cancer

Immune-related RNA signature predicts outcome of PD-1 inhibitor-combined GEMCIS therapy in advanced intrahepatic cholangiocarcinoma

Prognostic stratification based on m5C regulators acts as a novel biomarker for immunotherapy in hepatocellular carcinoma

Roles of CD4+ T cells as mediators of antitumor immunity

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Female offspring gestated in hypothyroxinemia and infected with human Metapneumovirus (hMPV) suffer a more severe infection and have a higher number of activated CD8+ T lymphocytes

Editorial: Emerging roles and mechanisms of stromal cells in carcinomas at the molecular level

Identification and validation of SNHG gene signature to predict malignant behaviors and therapeutic responses in glioblastoma

Role of B cells as antigen presenting cells

Tipping the scales: Immunotherapeutic strategies that disrupt immunosuppression and promote immune activation

Grass carp SERPINA1 inhibits GCRV infection through degrading CF2

Serological biomarkers predict immune-related adverse events and clinical benefit in patients with advanced gastrointestinal cancers

Novel immune scoring dynamic nomograms based on B7-H3, B7-H4, and HHLA2: Potential prediction in survival and immunotherapeutic efficacy for gallbladder cancer

The regulatory roles of T helper cells in distinct extracellular matrix characterization in breast cancer

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Hepatic damage caused by long-term high cholesterol intake induces a dysfunctional restorative macrophage population in experimental NASH

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Causal effects of gut microbiota on diabetic retinopathy: A Mendelian randomization study

Vitamin D3 deficiency induced intestinal inflammatory response of turbot through nuclear factor-κB/inflammasome pathway, accompanied by the mutually exclusive apoptosis and autophagy

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Immune depletion of the methylated phenotype of colon cancer is closely related to resistance to immune checkpoint inhibitors

Suitability of potyviral recombinant virus-like particles bearing a complete food allergen for immunotherapy vaccines

Red blood cell transfusions impact response rates to immunotherapy in patients with solid malignant tumors

IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes

Immune status for monitoring and treatment of bladder cancer

Harmonization and qualification of an IFN-γ Enzyme-Linked ImmunoSpot assay (ELISPOT) to measure influenza-specific cell-mediated immunity within the FLUCOP consortium

Are neurodegenerative diseases associated with an increased risk of inflammatory bowel disease? A two-sample Mendelian randomization study

Local Immunoglobulin E in nasal polyps: Role and modulation

Systemic immune-inflammation index and bone mineral density in postmenopausal women: A cross-sectional study of the national health and nutrition examination survey (NHANES) 2007-2018

Interactions between the gut microbiota-derived functional factors and intestinal epithelial cells – implication in the microbiota-host mutualism

Identification of clinical prognostic features of esophageal cancer based on m6A regulators

Global trends in research on oxidative stress associated with periodontitis from 1987 to 2022: A bibliometric analysis

Based on different immune responses under the glucose metabolizing type of papillary thyroid cancer and the response to anti-PD-1 therapy

Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity

Engineering the common cold to be a live-attenuated SARS-CoV-2 vaccine

Case report: Documentation of cutaneous only pemphigus vulgaris without history of mucosal lesions in North America

Profiling genes encoding the adaptive immune receptor repertoire with gAIRR Suite

LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager

Integrated genomic, transcriptomic and metabolomic analysis reveals MDH2 mutation-induced metabolic disorder in recurrent focal segmental glomerulosclerosis

Corrigendum: The effects of COVID-19 on the placenta during pregnancy

Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunity

The effect of serum IL-2 levels on the prognosis of primary biliary cholangitis-related liver failure and the preliminary exploration of its mechanism

Case Report: Association between cyclic neutropenia and SRP54 deficiency

Comparable bidirectional neutrophil immune dysregulation between Kawasaki disease and severe COVID-19

Serum proteomic networks associate with pre-clinical rheumatoid arthritis autoantibodies and longitudinal outcomes

Pretreatment with IPA ameliorates colitis in mice: Colon transcriptome and fecal 16S amplicon profiling

Characteristics of the immune microenvironment and their clinical significance in non-small cell lung cancer patients with ALK-rearranged mutation

The use of ELISA is comparable to immunoprecipitation in the detection of selected myositis-specific autoantibodies in a European population

Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders

Annexin A2 regulates Mycoplasma bovis adhesion and invasion to embryo bovine lung cells affecting molecular expression essential to inflammatory response

Improvement of gut microbiome and intestinal permeability following splenectomy plus pericardial devascularization in hepatitis B virus-related cirrhotic portal hypertension

Large-scale bulk RNA-seq analysis defines immune evasion mechanism related to mast cell in gliomas

Combined – whole blood and skin fibroblasts- transcriptomic analysis in Psoriatic Arthritis reveals molecular signatures of activity, resistance and early response to treatment

Affinity capillary electrophoresis – mass spectrometry permits direct binding assessment of IgG and FcγRIIa in a glycoform-resolved manner

PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during flu

Five decades of clinical assessment of whole-sporozoite malaria vaccines

The cardiometabolic conditions of psoriatic disease

Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities

Non-coding RNA-mediated high expression of SFXN3 as a prognostic biomarker associated with paclitaxel resistance and immunosuppressive microenvironment in head and neck cancer

A role for an HTLV-1 vaccine?

Common aquatic pollutants modify hemocyte immune responses in Biomphalaria glabrata

Evaluation and comparison of adaptive immunity through analyzing the diversities and clonalities of T-cell receptor repertoires in the peripheral blood

Harnessing the immune system by targeting immune checkpoints: Providing new hope for Oncotherapy

Integrated genomic, transcriptomic, and epigenetic analyses identify a leukotriene synthesis-related M2 macrophage gene signature that predicts prognosis and treatment vulnerability in gliomas

Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions

Delivery of antigen to porcine dendritic cells by fusing antigen with porcine dendritic cells targeting peptide

The importance of booster vaccination in the context of Omicron wave

Pan-cancer analysis reveals interleukin-17 family members as biomarkers in the prediction for immune checkpoint inhibitor curative effect

mRNA vaccination drives differential mucosal neutralizing antibody profiles in naïve and SARS-CoV-2 previously-infected individuals

Adenosinergic axis and immune checkpoint combination therapy in tumor: A new perspective for immunotherapy strategy

Jmjd3/IRF4 axis aggravates myeloid fibroblast activation and m2 macrophage to myofibroblast transition in renal fibrosis

Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity

Cooperative action of SP-A and its trimeric recombinant fragment with polymyxins against Gram-negative respiratory bacteria

A possible mechanism of Cry7Ab4 protein in delaying pupation of Plutella xylostella larvae

Editorial: alternative antigen processing and presentation in immune disorders

Association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis

Cytokine competent gut-joint migratory T Cells contribute to inflammation in the joint

Whole course of treatment of autoimmune progesterone dermatitis that had spontaneously resolved during pregnancy: A case report and review of the literature

Peripheral immune signature resembles tumor microenvironment and predicts clinical outcomes in head and neck squamous cell carcinoma

Investigation of the association between the genetic polymorphisms of the co-stimulatory system and systemic lupus erythematosus

A comprehensively prognostic and immunological analysis of actin-related protein 2/3 complex subunit 5 in pan-cancer and identification in hepatocellular carcinoma

IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohort

Longitudinal profiles of plasma gelsolin, cytokines and antibody expression predict COVID-19 severity and hospitalization outcomes

Multi‑institutional development and validation of a nomogram to predict prognosis of early-onset gastric cancer patients

Developing dendritic cell for SARS-CoV-2 vaccine: Breakthrough in the pandemic

Detection of innate immune response modulating impurities (IIRMI) in therapeutic peptides and proteins: Impact of excipients

Improvement of the sepsis survival rate by adenosine 2a receptor antagonists depends on immune regulatory functions of regulatory T-cells

Editorial: The role of red blood cells in the immune response of fish

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Emerging trends and research foci of oncolytic virotherapy for central nervous system tumors: A bibliometric study

Esaxerenone inhibits the macrophage-to-myofibroblast transition through mineralocorticoid receptor/TGF-β1 pathway in mice induced with aldosterone

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TLR2-induced CD8+ T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis

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The role of virus infections in Sjögren’s syndrome

Evaluation of the immunomodulatory effects of interleukin-10 on peripheral blood immune cells of COVID-19 patients: Implication for COVID-19 therapy

Interferon add-on therapy increased clinical cure significantly for interferon-experienced chronic hepatitis B patients with low HBsAg

Influence of Eimeria maxima coccidia infection on gut microbiome diversity and composition of the jejunum and cecum of indigenous chicken

The cuproptosis-associated 13 gene signature as a robust predictor for outcome and response to immune- and targeted-therapies in clear cell renal cell carcinoma

Increased risk of early-onset childhood systemic lupus erythematosus for children born to affected parents: A nationwide child-parent cohort study

Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients

Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells

Perspectives on the mechanism of pyroptosis after intracerebral hemorrhage

Deciphering the endometrial immune landscape of RIF during the window of implantation from cellular senescence by integrated bioinformatics analysis and machine learning

Tumor cell-based vaccine contributes to local tumor irradiation by eliciting a tumor model-dependent systemic immune response

Immunotherapy of targeting MDSCs in tumor microenvironment

Targeting lipid metabolism reprogramming of immunocytes in response to the tumor microenvironment stressor: A potential approach for tumor therapy

Severe aplastic anemia patients with infection who received an allogeneic hematopoietic stem cell transplantation had a better chance: Long-term outcomes of a multicenter study

RAB20 deficiency promotes the development of silicosis via NLRP3 inflammasome

Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID

Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers

Exploration of shared TF-miRNA‒mRNA and mRNA-RBP-pseudogene networks in type 2 diabetes mellitus and breast cancer

Intratumoral CD73: An immune checkpoint shaping an inhibitory tumor microenvironment and implicating poor prognosis in Chinese melanoma cohorts

Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques

Regulation of emergency granulopoiesis during infection

Cardiac alterations following experimental hip fracture - inflammaging as independent risk factor

IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike

The role of tumor-associated macrophages and soluble mediators in pulmonary metastatic melanoma

Adaptive transcriptomic and immune infiltrate responses in the tumor immune microenvironment following neoadjuvant chemotherapy in high grade serous ovarian cancer reveal novel prognostic associations and activation of pro-tumorigenic pathways

Initial activation of STAT2 induced by IAV infection is critical for innate antiviral immunity

The bidirectional biological interplay between microbiome and viruses in periodontitis and type-2 diabetes mellitus

Clinical application status and prospect of the combined anti-tumor strategy of ablation and immunotherapy

Immune features of the peritumoral stroma in pancreatic ductal adenocarcinoma

Macrophages in periapical lesions: Potential roles and future directions

IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation

Antifungal immunity mediated by C-type lectin receptors may be a novel target in immunotherapy for urothelial bladder cancer

Safety monitoring in inactivated COVID-19 vaccines by clinical pharmacists from a single center in China

Mechanism of activation of porcine dendritic cells by an α-D-glucan nanoparticle adjuvant and a nanoparticle/poly(I:C) combination adjuvant

Early-life stress and dietary fatty acids impact the brain lipid/oxylipin profile into adulthood, basally and in response to LPS

Extracellular vesicles from Listeria monocytogenes-infected dendritic cells alert the innate immune response

Clinical application of transcranial magnetic stimulation in multiple sclerosis

Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond

Cytopenia after chimeric antigen receptor T cell immunotherapy in relapsed or refractory lymphoma

Specific transcriptional programs differentiate ICOS from CD28 costimulatory signaling in human Naïve CD4+ T cells

Single cell RNA sequencing reveals hemocyte heterogeneity in Biomphalaria glabrata: Plasticity over diversity

Identifying key mutations of radioresponsive genes in esophageal squamous cell carcinoma

Prototheca bovis induces autophagy in bovine mammary epithelial cells via the HIF-1α and AMPKα/ULK1 pathway

SARS-CoV-2 vaccination in androgen sensitive phenotypes – A study on associated factors for SARS-CoV-2 vaccination and its adverse effects among androgenetic alopecia and benign prostate hyperplasia patients

Ferulic acid alleviates retinal neovascularization by modulating microglia/macrophage polarization through the ROS/NF-κB axis

Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice

Tumor accomplice: T cell exhaustion induced by chronic inflammation

Research advance of natural products in tumor immunotherapy

A versatile toolkit for overcoming AAV immunity

Application of artificial liver in immune-related liver injury induced by immune checkpoint inhibitor: Case reports and review of the literature

Potential mouse models of coronavirus-related immune injury

COVID-19 vaccine type-dependent differences in immunogenicity and inflammatory response: BNT162b2 and ChAdOx1 nCoV-19

Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice

The efficacy and safety of tacrolimus on top of glucocorticoids in the management of IIM-ILD: A retrospective and prospective study

The Th1/Tfh-like biased responses elicited by the rASP-1 innate adjuvant are dependent on TRIF and Type I IFN receptor pathways

Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination

Combination of phototherapy with immune checkpoint blockade: Theory and practice in cancer

Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens

ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis

Humoral antimalaria immune response in Nigerian children exposed to helminth and malaria parasites

Disruption of cellular immune response among male rotating night shift workers in Spain– The HORMONIT study

Targeting inflammation and immune activation to improve CTLA4-Ig-based modulation of transplant rejection

The role of the different CD3γ domains in TCR expression and signaling

Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle

Immunotherapy resistance in esophageal cancer: Possible mechanisms and clinical implications

Integrated multi-omics reveals the activated retinal microglia with intracellular metabolic reprogramming contributes to inflammation in STZ-induced early diabetic retinopathy

Integrated analysis of immune parameters, miRNA-mRNA interaction, and immune genes expression in the liver of rainbow trout following infectious hematopoietic necrosis virus infection

Prognostic value of PD-1, PD-L1 and PD-L2 deserves attention in head and neck cancer

Role of nuclear receptor PXR in immune cells and inflammatory diseases

Host inflammatory response is the major factor in the progression of Chlamydia psittaci pneumonia

Immunomodulatory effects of regorafenib: Enhancing the efficacy of anti-PD-1/PD-L1 therapy

Dynamic miRNA profile of host T cells during early hepatic stages of Schistosoma japonicum infection

Ciltacabtagene autoleucel: The second anti-BCMA CAR T-cell therapeutic armamentarium of relapsed or refractory multiple myeloma

Environmental factors influencing the risk of ANCA-associated vasculitis

Aberrant expansion of follicular helper T cell subsets in patients with systemic lupus erythematosus

Outbreak of Ichthyophthirius multifiliis associated with Aeromonas hydrophila in Pangasianodon hypophthalmus: The role of turmeric oil in enhancing immunity and inducing resistance against co-infection

Targeting immunometabolism mediated by the IDO1 Pathway: A new mechanism of immune resistance in endometrial cancer

Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years

The potential roles of interleukin-25 in infectious diseases

Deciphering the immune landscape dominated by cancer-associated fibroblasts to investigate their potential in indicating prognosis and guiding therapeutic regimens in high grade serous ovarian carcinoma

Effects of sex steroids on thymic epithelium and thymocyte development

FGFBP1 as a potential biomarker predicting bacillus Calmette–Guérin response in bladder cancer

Case report: The MSI-L/p-MMR metastatic rectal cancer patient who failed systemic therapy responds to anti-PD-1 immunotherapy after stereotactic body radiation-therapy

Ion channel Piezo1 activation promotes aerobic glycolysis in macrophages

Altered intraperitoneal immune microenvironment in patients with peritoneal metastases from gastric cancer

A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes

Impact of hypertension on long-term humoral and cellular response to SARS-CoV-2 infection

Construction and characterization of a contagious ecthyma virus double-gene deletion strain and evaluation of its potential as a live-attenuated vaccine in goat

Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review

The evolution of humoral immune responses to past and novel influenza virus strains gives evidence for antigenic seniority

The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles

Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine

Increased serum level of alpha-2 macroglobulin and its production by B-lymphocytes in chronic lymphocytic leukemia

Haploidentical peripheral blood stem cell transplantation combined with unrelated cord blood in hematologic malignancy patients: A report of 80 cases

High-throughput sequencing unravels the cell heterogeneity of cerebrospinal fluid in the bacterial meningitis of children

Dysbiosis of human tumor microbiome and aberrant residence of Actinomyces in tumor-associated fibroblasts in young-onset colorectal cancer

Costimulation blockade and Tregs in solid organ transplantation

Clinical predictive value of naïve and memory T cells in advanced NSCLC

Synergistic targeting of immunologic pathways to empower durable tolerance therapies

Adipose tissue macrophage in obesity-associated metabolic diseases

Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases

Programmed Cell Death-Ligand-1 expression in Bladder Schistosomal Squamous Cell Carcinoma – There’s room for Immune Checkpoint Blockage?

Gain-of-function defects in toll-like receptor 8 shed light on the interface between immune system and bone marrow failure disorders

The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment

Transcriptional analysis highlights three distinct immune profiles of high-risk oral epithelial dysplasia

Definition of a new blood cell count score for early survival prediction for non-small cell lung cancer patients treated with atezolizumab: Integrated analysis of four multicenter clinical trials

Hemizygous nonsense variant in the moesin gene (MSN) leads to a new autoimmune phenotype of Immunodeficiency 50

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Activation and regulation mechanisms of NOD-like receptors based on structural biology

Content Provider	frontiers
Author	Ohto, Umeharu
Abstract	Innate immunity is a primary defense system against microbial infections. Innate immune pattern recognition receptors (PRRs) play pivotal roles in detection of invading pathogens. When pathogens, such as bacteria and viruses, invade our bodies, their components are recognized by PRRs as pathogen-associated molecular patterns (PAMPs), activating the innate immune system. Cellular components such as DNA and RNA, acting as damage-associated molecular patterns (DAMPs), also activate innate immunity through PRRs under certain conditions. Activation of PRRs triggers inflammatory responses, interferon-mediated antiviral responses, and the activation of acquired immunity. Research on innate immune receptors is progressing rapidly. A variety of these receptors has been identified, and their regulatory mechanisms have been elucidated. Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) constitute a major family of intracellular PRRs and are involved in not only combating pathogen invasion but also maintaining normal homeostasis. Some NLRs are known to form multi-protein complexes called inflammasomes, a process that ultimately leads to the production of inflammatory cytokines and induces pyroptosis through the proteolytic cascade. The aberrant activation of NLRs has been found to be associated with autoimmune diseases. Therefore, NLRs are considered targets for drug discovery, such as for antiviral drugs, immunostimulants, antiallergic drugs, and autoimmune disease drugs. This review summarizes our recent understanding of the activation and regulation mechanisms of NLRs, with a particular focus on their structural biology. These include NOD2, neuronal apoptosis inhibitory protein (NAIP)/NLRC4, NLR family pyrin domain containing 1 (NLRP1), NLRP3, NLRP6, and NLRP9. NLRs are involved in a variety of diseases, and their detailed activation mechanisms based on structural biology can aid in developing therapeutic agents in the future.
ISSN	16643224
DOI	10.3389/fimmu.2022.953530
Volume Number	13
Journal	Frontiers in Immunology
Language	English
Publisher Date	2022-09-15
Access Restriction	Open
Subject Keyword	NOD-like receptors (NLRs) Inflammasome Innate immunity Pattern Recognition Receptors Pathogen-associated molecular patterns Damageassociated molecular patterns
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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