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| Content Provider | frontiers |
|---|---|
| Author | Ciabattini, Annalisa Pastore, Gabiria Fiorino, Fabio Polvere, Jacopo Lucchesi, Simone Pettini, Elena Auddino, Stefano Rancan, Ilaria Durante, Miriam Miscia, Michele Rossetti, Barbara Fabbiani, Massimiliano Montagnani, Francesca Medaglini, Donata |
| Abstract | SARS-CoV-2 mRNA vaccines have demonstrated high efficacy and immunogenicity, but limited information is currently available on memory B cell generation and long-term persistence. Here, we investigated spike-specific memory B cells and humoral responses in 145 subjects, up to 6 months after the BNT162b2 vaccine (Comirnaty) administration. Spike-specific antibodies peaked 7 days after the second dose and significant antibody titers and ACE2/RBD binding inhibiting activity were still observed after 6 months, despite a progressive decline over time. Concomitant to antibody reduction, spike-specific memory B cells, mostly IgG class-switched, increased in the blood of vaccinees and persisted 6 months after vaccination. Following the in vitro restimulation, circulating memory B cells reactivated and produced spike-specific antibodies. A high frequency of spike-specific IgG+ plasmablasts, identified by computational analysis 7 days after boost, positively correlated with the generation of IgG+ memory B cells at 6 months. These data demonstrate that mRNA BNT162b2 vaccine elicits strong B cell immunity with spike-specific memory B cells that still persist 6 months after vaccination, playing a crucial role for a rapid response to SARS-CoV-2 virus encounter. |
| ISSN | 16643224 |
| DOI | 10.3389/fimmu.2021.740708 |
| Volume Number | 12 |
| Journal | Frontiers in Immunology |
| Language | English |
| Publisher Date | 2021-09-28 |
| Access Restriction | Open |
| Subject Keyword | SARS-CoV-2 Memory B cells COVID-19 BNT162b2 vaccine Vaccination |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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