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| Content Provider | frontiers |
|---|---|
| Author | Hou, Haifeng Yang, Huan Liu, Pengcheng Huang, Changwu Wang, Meng Li, Yuejin Zhu, Mingsong Wang, Jing Xu, Yuan Wang, Youxin Ma, Qingwei Li, Dong Liao, Pu Wang, Wei |
| Abstract | Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N-glycome between COVID-19 patients and healthy controls. A case-control study was conducted, in which 104 COVID-19 patients and 104 age- and sex-matched healthy individuals were recruited. Serum IgG N-glycome composition was analyzed by hydrophilic interaction liquid chromatography with the ultra-high-performance liquid chromatography (HILIC-UPLC) approach. COVID-19 patients have a decreased level of IgG fucosylation, which upregulates antibody-dependent cell cytotoxicity (ADCC) in acute immune responses. In severe cases, a low level of IgG sialylation contributes to the ADCC-regulated enhancement of inflammatory cytokines. The decreases in sialylation and galactosylation play a role in COVID-19 pathogenesis via the activation of the lectin-initiated alternative complement pathway. IgG N-glycosylation underlines the complex clinical phenotypes of SARS-CoV-2 infection. |
| ISSN | 16643224 |
| DOI | 10.3389/fimmu.2021.748566 |
| Volume Number | 12 |
| Journal | Frontiers in Immunology |
| Language | English |
| Publisher Date | 2021-09-23 |
| Access Restriction | Open |
| Subject Keyword | COVID-19 SARS-CoV-2 Case-control study Glycosylation IgG |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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