NDLI: Antibody Titer Kinetics and SARS-CoV-2 Infections Six Months after Administration with the BNT162b2 Vaccine

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Antibody Titer Kinetics and SARS-CoV-2 Infections Six Months after Administration with the BNT162b2 Vaccine

Content Provider	MDPI
Author	Ferrari, Davide Clementi, Nicola Criscuolo, Elena Ambrosi, Alessandro Corea, Francesca Resta, Chiara Di Tomaiuolo, Rossella Mancini, Nicasio Locatelli, Massimo Plebani, Mario Banfi, Giuseppe
Copyright Year	2021
Description	Background: Studies reporting the long-term humoral response after receiving the BNT162b2 COVID-19 vaccine are important to drive future vaccination strategies. Yet, available literature is scarce. Covidiagnostix is a multicenter study designed to assess the antibody response in >1000 healthcare professionals (HCPs) who received the BNT162b2 vaccine. Methods: Serum was tested at time-0 $(T_{0}$), before the first dose, $T_{1}$, $T_{2,}$ and $T_{3}$, respectively, 21, 42, and 180 days after $T_{0}$. Antibodies against the SARS-CoV-2 nucleocapsid-protein were measured to assess SARS-CoV-2 infections, whereas antibodies against the receptor-binding domain of the spike protein were measured to assess the vaccine response. Neutralization activity against the D614G, B.1.1.7, and B.1.351 variants were also analyzed. Results: Six months post-vaccination HCPs showed an antibody titer decrease of approximately 70%, yet, the titer was still one order of magnitude higher than that of seropositive individuals before vaccination. We identified 12 post-vaccination infected HCPs. None showed severe symptoms. Interestingly, most of them showed titers at $T_{2}$ above the neutralization thresholds obtained from the neutralization activity experiments. Conclusion: Vaccination induces a humoral response which is well detectable even six months post-vaccination. Vaccination prevents severe COVID-19 cases, yet post-vaccination infection is possible even in the presence of a high anti-S serum antibody titer.
Starting Page	1357
e-ISSN	2076393X
DOI	10.3390/vaccines9111357
Journal	Vaccines
Issue Number	11
Volume Number	9
Language	English
Publisher	MDPI
Publisher Date	2021-11-19
Access Restriction	Open
Subject Keyword	Vaccines Womens Studies Covid-19 Serological Test Mrna Vaccine Roche Anti-sars-cov-2-s Immune Response Vaccination
Content Type	Text
Resource Type	Article

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