Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in China.

Content Provider	Europe PMC
Author	Tang, Jingyun Liu, Humin Wang, Qing Gu, Xiaobo Wang, Jia Li, Wenjun Luo, Yinglan Li, Yan Deng, Lan Luo, Yue Du, Xinman Tan, Donglin Fu, Xuemei Chen, Xue
Copyright Year	2023
Abstract	BackgroundDemographic information has been shown to help predict high antibody titers of COVID-19 convalescent plasma (CCP) in CCP donors. However, there is no research on the Chinese population and little evidence on whole-blood donors. Therefore, we aimed to investigate these associations among Chinese blood donors after SARS-CoV-2 infection.MethodsIn this cross-sectional study, 5,064 qualified blood donors with confirmed or suspected SARS-CoV-2 infection completed a self-reported questionnaire and underwent tests of SARS-CoV-2 Immunoglobulin G (IgG) antibody and ABO blood type. Logistic regression models were used to calculate odds ratios (ORs) for high SARS-CoV-2 IgG titers according to each factor.ResultsTotally, 1,799 participants (with SARS-CoV-2 IgG titers≥1:160) had high-titer CCPs. Multivariable analysis showed that a 10-year increment in age and earlier donation were associated with higher odds of high-titer CCP, while medical personnel was associated with lower odds. The ORs (95% CIs) of high-titer CCP were 1.17 (1.10–1.23, p< 0.001) and 1.41 (1.25-1.58, p< 0.001) for each 10-year increment in age and earlier donation, respectively. The OR of high-titer CCP was 0.75 (0.60-0.95, p = 0.02) for medical personnel. Female early donors were associated with increased odds of high-titer CCP, but this association was insignificant for later donors. Donating after 8 weeks from the onset was associated with decreased odds of having high-titer CCP compared to donating within 8 weeks from the onset, and the HR was 0.38 (95% CI: 0.22-0.64, p <0.001). There was no significant association between ABO blood type or race and the odds of high-titer CCP.DiscussionOlder age, earlier donation, female early donors, and non-medical-related occupations are promising predictors of high-titer CCP in Chinese blood donors. Our findings highlight the importance of CCP screening at the early stage of the pandemic.
Page Count	8
Journal	Frontiers in Immunology
Volume Number	14
PubMed Central reference number	PMC10303911
PubMed reference number	37388736
e-ISSN	16643224
DOI	10.3389/fimmu.2023.1191479
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2023-06-14
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Copyright © 2023 Tang, Liu, Wang, Gu, Wang, Li, Luo, Li, Deng, Luo, Du, Tan, Fu and Chen
Subject Keyword	SARS-CoV-2 IgG titer convalescent plasma screening COVID-19 Chinese cross-sectional study whole-blood donors
Content Type	Text
Resource Type	Article
Subject	Immunology Immunology and Allergy