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NRF2 in the Epidermal Pigmentary System.
| Content Provider | Europe PMC |
|---|---|
| Author | Ogawa, Tatsuya Ishitsuka, Yosuke |
| Editor | Lastres-Becker, Isabel |
| Copyright Year | 2022 |
| Abstract | Melanogenesis is a major part of the environmental responses and tissue development of the integumentary system. The balance between reduction and oxidation (redox) governs pigmentary responses, for which coordination among epidermal resident cells is indispensable. Here, we review the current understanding of melanocyte biology with a particular focus on the “master regulator” of oxidative stress responses (i.e., the Kelch-like erythroid cell-derived protein with cap‘n’collar homology-associated protein 1-nuclear factor erythroid-2-related factor 2 system) and the autoimmune pigment disorder vitiligo. Our investigation revealed that the former is essential in pigmentogenesis, whereas the latter results from unbalanced redox homeostasis and/or defective intercellular communication in the interfollicular epidermis (IFE). Finally, we propose a model in which keratinocytes provide a “niche” for differentiated melanocytes and may “imprint” IFE pigmentation. |
| Journal | Biomolecules |
| Volume Number | 13 |
| PubMed Central reference number | PMC9855619 |
| Issue Number | 1 |
| PubMed reference number | 36671405 |
| e-ISSN | 2218273X |
| DOI | 10.3390/biom13010020 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-12-22 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors. |
| Subject Keyword | antioxidant melanocyte NRF2 oxidative stress reactive oxygen species redox vitiligo |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Molecular Biology |
