Modulation of cellular redox homeostasis by the endocannabinoid system.

Content Provider	Europe PMC
Author	Lipina, Christopher Hundal, Harinder S.
Copyright Year	2016
Abstract	The endocannabinoid system (ECS) and reactive oxygen species (ROS) constitute two key cellular signalling systems that participate in the modulation of diverse cellular functions. Importantly, growing evidence suggests that cross-talk between these two prominent signalling systems acts to modulate functionality of the ECS as well as redox homeostasis in different cell types. Herein, we review and discuss evidence pertaining to ECS-induced regulation of ROS generating and scavenging mechanisms, as well as highlighting emerging work that supports redox modulation of ECS function. Functionally, the studies outlined reveal that interactions between the ECS and ROS signalling systems can be both stimulatory and inhibitory in nature, depending on cell stimulus, the source of ROS species and cell context. Importantly, such cross-talk may act to maintain cell function, whereas abnormalities in either system may propagate and undermine the stability of both systems, thereby contributing to various pathologies associated with their dysregulation.
Journal	Open Biology
Volume Number	6
PubMed Central reference number	PMC4852457
Issue Number	4
PubMed reference number	27248801
e-ISSN	20462441
DOI	10.1098/rsob.150276
Language	English
Publisher	The Royal Society
Publisher Date	2016-04-27
Access Restriction	Open
Rights License	Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. © 2016 The Authors.
Subject Keyword	endocannabinoid system reactive oxygen species antioxidant redox homeostasis oxidative stress cannabinoid receptor
Content Type	Text
Resource Type	Article
Subject	Immunology Biochemistry, Genetics and Molecular Biology Neuroscience