Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease.

Content Provider	Europe PMC
Author	Ushio-Fukai, Masuko Ash, Dipankar Nagarkoti, Sheela Belin de Chantemèle, Eric J. Fulton, David J.R. Fukai, Tohru
Copyright Year	2021
Abstract	Reactive oxygen species (ROS; e.g., superoxide [O2•−] and hydrogen peroxide [H2O2]) and reactive nitrogen species (RNS; e.g., nitric oxide [NO•]) at the physiological level function as signaling molecules that mediate many biological responses, including cell proliferation, migration, differentiation, and gene expression. By contrast, excess ROS/RNS, a consequence of dysregulated redox homeostasis, is a hallmark of cardiovascular disease. Accumulating evidence suggests that both ROS and RNS regulate various metabolic pathways and enzymes. Recent studies indicate that cells have mechanisms that fine-tune ROS/RNS levels by tight regulation of metabolic pathways, such as glycolysis and oxidative phosphorylation. The ROS/RNS-mediated inhibition of glycolytic pathways promotes metabolic reprogramming away from glycolytic flux toward the oxidative pentose phosphate pathway to generate nicotinamide adenine dinucleotide phosphate (NADPH) for antioxidant defense. This review summarizes our current knowledge of the mechanisms by which ROS/RNS regulate metabolic enzymes and cellular metabolism and how cellular metabolism influences redox homeostasis and the pathogenesis of disease. A full understanding of these mechanisms will be important for the development of new therapeutic strategies to treat diseases associated with dysregulated redox homeostasis and metabolism. Antioxid. Redox Signal. 34, 1319–1354.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8418449&blobtype=pdf
Page Count	36
ISSN	15230864
Volume Number	34
DOI	10.1089/ars.2020.8161
PubMed Central reference number	PMC8418449
Issue Number	16
PubMed reference number	33899493
Journal	Antioxidants & Redox Signaling [Antioxid Redox Signal]
e-ISSN	15577716
Language	English
Publisher	Mary Ann Liebert, Inc., publishers
Publisher Date	2021-06-01
Publisher Place	USA
Access Restriction	Open
Rights License	Copyright 2021, Mary Ann Liebert, Inc., publishers
Subject Keyword	metabolism oxidative stress redox signaling reactive oxygen species reactive nitrogen species
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology Medicine Clinical Biochemistry Molecular Biology Biochemistry