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Clinicopathological analysis of diffuse large B-cell lymphoma lacking surface immunoglobulin light chain restriction on flow cytometry.
| Content Provider | Europe PMC |
|---|---|
| Author | Nakaya, Yosuke Sakaida, Miho Yoshida, Masahiro Shimizu, Katsujun Yagi, Naoko Tsutsumi, Minako Yoshimura, Takuro Hayashi, Yoshiki Nakao, Takafumi Inoue, Takeshi Yamane, Takahisa |
| Copyright Year | 2021 |
| Abstract | Although diffuse large B-cell lymphoma (DLBCL) occasionally lacks surface immunoglobulin light chain restriction (iLCR) on flow cytometry (FCM), little evidence is available for iLCR-negative DLBCL. We retrospectively compared clinicopathological features of iLCR-positive and iLCR-negative DLBCL diagnosed at our institute between April 2007 and March 2018. iLCR-positive was defined as a κ/λ ratio less than 0.5 or greater than 3 in the gated population on dual-color FCM, and iLCR-negative as other values. Of 81 DLBCL cases with available immunophenotyping by FCM, 63 iLCR-positive DLBCL (78%) and 18 iLCR-negative DLBCL (22%) cases were identified. Survival outcomes of patients with iLCR-negative DLBCL were comparable with those of patients with iLCR-positive DLBCL. Pathological analysis revealed no significant difference except for the lower expression of BCL6 in iLCR-negative DLBCL (12.5% vs 65.5%, p < 0.001), although there was a slightly higher frequency of necrosis (47.1% vs 20.7%, p = 0.058) and lower expression of CD10 (11.8% vs 35.0%, p = 0.078) in iLCR-negative DLBCL than in iLCR-positive DLBCL. The underlying mechanism remains unclear; however, low expression of germinal center markers and tumor necrosis may be associated with the loss of iLCR in DLBCL. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9010494&blobtype=pdf |
| ISSN | 13464280 |
| Journal | Journal of Clinical and Experimental Hematopathology : JCEH [J Clin Exp Hematop] |
| Volume Number | 62 |
| DOI | 10.3960/jslrt.21017 |
| PubMed Central reference number | PMC9010494 |
| Issue Number | 1 |
| PubMed reference number | 34707034 |
| e-ISSN | 18809952 |
| Language | English |
| Publisher | JSLRT |
| Publisher Date | 2021-10-26 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of theCreative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License. © 2021 by The Japanese Society for Lymphoreticular Tissue Research |
| Subject Keyword | diffuse large B-cell lymphoma flow cytometry immunoglobulin light chain restriction necrosis cell of origin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Hematology |
