NDLI: Usefulness of immunoglobulin light-chain restriction on immunocytochemical double staining for the cytological diagnosis of B cell non-Hodgkin's lymphoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shimoura, Yasumasa Sato, Yasuharu Takata, Katsuyoshi Orita, Yorihisa Nakamura, Satoko Mano, Shyouhei Yoshino, Tadashi
Description	Country affiliation: Japan Author Affiliation: Shimoura Y ( Department of Pathology, Kagawa Prefectural Central Hospital, Takamatsu, Japan.)
Abstract	OBJECTIVE: We examined the usefulness of light-chain restriction (LCR) on immunocytochemical double staining (IDS) for cytological diagnosis. STUDY DESIGN: We investigated LCR on IDS in 40 patients with proliferative lymphatic disorders (23 with B cell lymphoma, 13 with reactive lymphoid lesions, 2 with T cell lymphoma and 2 with Hodgkin's lymphoma). In addition, the results of flow cytometry (FCM) were compared in 34 of these patients. RESULTS: On IDS, LCR was detected in 21 of 23 patients (91.3%) with B cell lymphoma. On FCM, it was detected in 15 of 21 patients (71.4%) with B cell lymphoma. Neither IDS nor FCM showed LCR in any patients with reactive lesions, T cell lymphoma or Hodgkin's lymphoma. CONCLUSION: IDS facilitated the detection of LCR with a single specimen under morphological observation. The application of this procedure may improve the accuracy of cytological diagnosis.
File Format	HTM / HTML
ISSN	00015547
Issue Number	1
Volume Number	57
e-ISSN	19382650
Journal	Acta Cytologica
Language	English
Publisher	Karger
Publisher Date	2013-01-01
Publisher Place	Switzerland
Access Restriction	Subscribed
Subject Keyword	Discipline Cell Biology Cytodiagnosis Methods Immunoglobulin Light Chains Analysis Immunohistochemistry Lymphoma, B-cell Diagnosis Flow Cytometry Humans Immunology Immunophenotyping Sensitivity And Specificity Journal Article
Content Type	Text
Resource Type	Article
Subject	Histology Pathology and Forensic Medicine

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