Diffuse large B-cell lymphoma (DLBCL) with significant intravascular invasion. Close resemblance of its clinicopathological features to intravascular large B-cell lymphoma, but not to DLBCL-not otherwise specified.

Content Provider	Europe PMC
Author	Itami, Hiroe Nakamine, Hirokazu Kubo, Masayuki Ogawa, Kohei Tani, Rina Nakamura, Shinji Takeda, Maiko Nitta, Yuji Uchiyama, Tomoko Fujii, Tomomi Hatakeyama, Kinta Ohbayashi, Chiho
Copyright Year	2021
Abstract	Intravascular large B-cell lymphoma (IVLBCL) is defined by the World Health Organization (WHO) Classification as one type of extranodal large B-cell lymphoma and it is characterized by the selective growth of lymphoma cells within blood vessels with minimal extravascular invasion. According to the criteria, however, several reported cases of IVLBCL with significant extravascular invasion cannot be classified as IVLBCL. The purpose of the present study was to assess the clinicopathological significance of the WHO criteria for IVLBCL. We characterized clinical, histopathological, and immunohistochemical features of 11 patients with extranodal diffuse large B-cell lymphoma (DLBCL) with significant intravascular invasion (DLBCL-IV), and statistically compared their features with those of 11 patients with IVLBCL and 15 patients with extranodal DLBCL with virtually no intravascular invasion (DLBCL-noIV). When compared with the DLBCL-noIV group, the DLBCL-IV group was characterized by significantly higher rates of splenomegaly, hemophagocytosis, advanced stage disease, and CD5 expression; higher average platelet count, serum lactate dehydrogenase level, and serum ferritin level. Progression-free survival was significantly shorter in the DLBCL-IV group than the DLBCL-noIV group. In contrast, there were no significant differences in clinicopathological features between the DLBCL-IV and the IVLBCL groups. Our study suggests that DLBCL-IV should be regarded as IVLBCL-related.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8519243&blobtype=pdf
ISSN	13464280
Journal	Journal of Clinical and Experimental Hematopathology : JCEH [J Clin Exp Hematop]
Volume Number	61
DOI	10.3960/jslrt.20066
PubMed Central reference number	PMC8519243
Issue Number	3
PubMed reference number	34193753
e-ISSN	18809952
Language	English
Publisher	JSLRT
Publisher Date	2021-06-30
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of theCreative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License. © 2021 by The Japanese Society for Lymphoreticular Tissue Research
Subject Keyword	Diffuse large B-cell lymphoma Intravascular lymphoma PD-L1
Content Type	Text
Resource Type	Article
Subject	Medicine Hematology