NDLI: Incidence and clinical significance of aberrant T-cell marker expression on diffuse large B-cell lymphoma cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Suzuki, Yuhko Yoshida, Tsutomu Wang, Guoqin Aoki, Takumi Katayama, Takuji Miyamoto, Shunsuke Miyazaki, Koji Iwabuchi, Keiichi Danbara, Mikio Nakayama, Meijin Horie, Ryouichi Nakamine, Hirokazu Sato, Yuichi Nakamura, Naoya Niitsu, Nozomi
Spatial Coverage	Japan
Description	Country affiliation: Japan Author Affiliation: Suzuki Y ( Department of Hematology, Kitasato University School of Medicine, Sagamihara, Japan.)
Abstract	INTRODUCTION: Aberrant expression of T-cell markers is occasionally observed in B-cell lymphomas. We conducted a retrospective study to establish its incidence and to determine its relationship with clinical features of patients with diffuse large B-cell lymphoma (DLBCL). PATIENTS AND METHODS: We reviewed DLBCL patients diagnosed between January 2002 and April 2009. Patients fulfilled the following criteria: (1) age >18 years, (2) HIV negative, (3) B-cell lymphoma confirmed by restricted expression of surface immunoglobulin light chains by flow cytometry (FCM). Aberrant T-cell marker expression (ATCME) was defined as positivity for CD2, CD3, CD4, CD7, and/or CD8 on DLBCL cells by FCM. Phenotyping was also performed by immunohistochemistry (IHC). Patients were grouped according to positive or negative ATCME and their clinical features including survival were compared. RESULTS: Of 150 patients, 11 (7.3%) showed ATCME; CD2 and CD7 were most often expressed. ATCME was less often detected and the signal was weaker using IHC. There were no statistically significant differences in clinical features between the two groups. CONCLUSIONS: FCM may be useful to detect ATCME in a small amount of lymphoma cells. The mechanism responsible for ATCME, and whether it contributes in any way to the pathogenesis of B-cell neoplastic transformation, requires clarification.
File Format	HTM / HTML
ISSN	00015792
Issue Number	4
Volume Number	130
e-ISSN	14219662
Journal	Acta Haematologica
Language	English
Publisher	Karger
Publisher Date	2013-01-01
Publisher Place	Switzerland
Access Restriction	Subscribed
Subject Keyword	Discipline Hematology Antigens, Cd Immunology Lymphoma, Large B-cell, Diffuse T-lymphocytes Adult Aged Aged, 80 And Over Antigens, Cd2 Antigens, Cd7 Female Flow Cytometry Humans Immunoglobulin Light Chains Immunohistochemistry Japan Epidemiology Mortality Pathology Male Middle Aged Retrospective Studies Journal Article Multicenter Study
Content Type	Text
Resource Type	Article
Subject	Hematology

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