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T cells in patients with B-cell chronic lymphocytic leukemia (B-CLL) and multiple myeloma (MM : An immunological study
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kiaii, Shahryar |
| Copyright Year | 2007 |
| Abstract | v LIST OF PUBLICATIONS vi 1 THE IMMUNE SYSTEM 1 1.1 INNATE (NON-SPECIFIC) IMMUNITY 1 1.1.1 Physical barriers 1 1.1.2 Physiological barriers 1 1.1.3 Phagocytes 1 1.1.4 Natural Killer (NK) Cells and Natural Killer T (NKT) cells 2 1.1.5 Discrimination of pathogens by the innate system 3 1.2 ADAPTIVE (SPECIFIC) IMMUNE SYSTEM 4 1.2.1 Formation of antigen-specific receptors on T and B cells 4 1.2.2 Lymphoid organs 5 1.2.3 Antigen presentation and the MHC molecules 6 1.2.4 Antigen recognition by T cells 7 1.2.5 TCR signaling 7 1.2.6 Effector T cells 10 1.2.6.1 Helper T cells 10 1.2.6.2 Cytotoxic T cells 10 1.2.7 Regulatory T cells (Treg) 11 1.2.8 B lymphocytes 11 1.2.8.1 T-cell dependent responses 12 1.2.8.2 T-cell independent responses 12 1.3 SUPERANTIGENS 12 2 MULTIPLE MYELOMA (MM) 14 2.1 EPIDEMIOLOGY 14 2.2 ETIOLOGY 14 2.3 GENETIC ALTERATIONS AND PATHOGENESIS 15 2.4 CLINICAL MANIFESTATIONS 15 2.5 DIAGNOSTIC CRITERIA 16 2.6 STAGING 16 2.7 PROGNOSTIC FACTORS 17 2.8 TREATMENT OF MM 18 2.9 BONE MARROW MICROENVIRONMENT 19 2.9.1 Osteoclasts 19 2.9.2 Osteoblasts 20 2.9.3 Other soluble factors 20 2.10 T CELLS IN MM 21 3 B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA (B-CLL) 23 3.1 EPIDEMIOLOGY 23 3.2 ETIOLOGY 24 3.3 CLINICAL MANIFESTATIONS 25 3.4 DIAGNOSTIC CRITERIA 26 3.5 STAGING 26 3.6 PROGNOSTIC FACTORS 28 3.6.1 Conventional prognostic factors 28 3.6.2 IgVH mutation status 28 3.6.3 ΞΆ-associated protein 70 (ZAP-70) 28 3.6.4 Chromosomal aberrations 29 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://openarchive.ki.se/xmlui/bitstream/handle/10616/39901/thesis.pdf;sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Thesis |
