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| Content Provider | The American Society of Mechanical Engineers (ASME) Digital Collection |
|---|---|
| Author | Sheriff, Jawaad Jesty, Jolyon Bluestein, Danny |
| Copyright Year | 2008 |
| Abstract | It is well established that shear stress exposure activates platelets, and it has been shown that this flow-induced activation contributes significantly to thromboembolic complications in mechanical heart valves (MHVs) [1]. In addition, the platelet activation state (PAS) assay has been demonstrated to be an efficient technique to measure procoagulant activity [2]. However, there is a lack of reliable models to predict platelet damage accumulation. Such a tool allows thrombogenicity optimization of implanted prosthetic devices. Prior to developing this tool, certain aspects of platelet behavior in response to shear stress must be elucidated. Of special importance for developing accountable damage accumulation models is the recovery potential of platelets during repeated passages through devices, when not exposed to the elevated stresses characterizing blood flow in these devices. To accomplish this, PAS measurements were conducted in a Hemodynamic Shearing Device (HSD), where platelets were exposed to prescribed waveforms with alternating periods of high and low shear stresses. |
| Sponsorship | Bioengineering Division |
| Starting Page | 825 |
| Ending Page | 826 |
| Page Count | 2 |
| File Format | |
| ISBN | 9780791843215 |
| DOI | 10.1115/SBC2008-192561 |
| Volume Number | ASME 2008 Summer Bioengineering Conference, Parts A and B |
| Conference Proceedings | ASME 2008 Summer Bioengineering Conference |
| Language | English |
| Publisher Date | 2008-06-25 |
| Publisher Place | Marco Island, Florida, USA |
| Access Restriction | Subscribed |
| Subject Keyword | Prostheses Heart valve prostheses Shearing (deformation) Shear stress Hemodynamics Damage Platelets Die cutting Flow (dynamics) Optimization Stress Blood flow |
| Content Type | Text |
| Resource Type | Article |
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