NDLI: Lysine acetylation regulates Bruton's tyrosine kinase in B cell activation.

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Lysine acetylation regulates Bruton's tyrosine kinase in B cell activation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Zhijian Sun, Jian Mai, Antonello
Description	Country affiliation: China Author Affiliation: Liu Z ( Laboratory of B-Cell and Autoantibody, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Shanghai JiaoTong University School of Medicine, Shanghai, China.)
Abstract	Bruton's tyrosine kinase (Btk) is essential for BCR signal transduction and has diverse functions in B cells. Although Btk has been extensively studied, the role of lysine acetylation in Btk regulation has not been reported. In this study, we show that BCR cross-linking induces histone lysine acetylation at the Btk promoter, correlating with marked recruitment of histone acetyltransferase E1A-associated 300-kDa protein (p300) to the locus. These effects enhance Btk promoter activity and increase the expression of Btk mRNA and protein. Consistent with these results, activated B cells display increased p300 expression and total histone acetyltransferase activity in vitro and in vivo, resulting in global histone acetylation. Interestingly, we found that BCR signaling induces Btk lysine acetylation mediated by p300. Moreover, lysine acetylation of Btk promotes its phosphorylation. Together, our results indicate a novel regulatory mechanism for Btk transcription and reveal a previously unrecognized posttranslational modification of the Btk protein and its association with phosphorylation in B cell activation.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	1
Volume Number	184
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2010-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-lymphocytes Metabolism Gene Expression Regulation Lymphocyte Activation Physiology Lysine Protein-tyrosine Kinases Biosynthesis Signal Transduction Immunology Acetylation Animals Blotting, Western Enzyme Inhibitors Pharmacology Fluorescent Antibody Technique Gene Expression Histones Mice Mice, Inbred C57bl Oligonucleotide Array Sequence Analysis Protein Processing, Post-translational Genetics Reverse Transcriptase Polymerase Chain Reaction Transfection P300-cbp Transcription Factors Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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